ArticleJournal of materials science. Materials in medicine2005
Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies.
Article in Journal of materials science. Materials in medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Novel Antibacterial Hydrogels Incorporating Quaternary Ammonium Monomethacrylate: A Pilot Study on Swelling Behavior and Biological Analysis.Materials (Basel, Switzerland) · 2026Article
- Article
- Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery.Biomedicines · 2023Review
- Challenges in Healing Wound: Role of Complementary and Alternative Medicine.Frontiers in nutrition · 2021Review
- Enhanced enzymatic activity and stability by in situ entrapment of α-Glucosidase within super porous p(HEMA) cryogels during synthesis.Biotechnology reports (Amsterdam, Netherlands) · 2020Article
- Development of an antimicrobial and antioxidant hydrogel/nano-electrospun wound dressing.RSC advances · 2020Article
- A Smart Drug Delivery System Based on Biodegradable Chitosan/Poly(allylamine hydrochloride) Blend Films.Pharmaceutics · 2020Article
- Intelligent Metal-Phenolic Metallogels as Dressings for Infected Wounds.Scientific reports · 2019Article
- Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles.Molecules (Basel, Switzerland) · 2019Review
- Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2018Review
- Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair.Progress in materials science · 2017Article
- Advances in the Fabrication of Antimicrobial Hydrogels for Biomedical Applications.Materials (Basel, Switzerland) · 2017Review
- Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications.Acta biomaterialia · 2015Article
- Synthesis of ciprofloxacin-conjugated poly (L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation.International journal of nanomedicine · 2014Article
- Antimicrobial hydrogels for the treatment of infection.Biopolymers · 2013Review
- Bacterial growth kinetics under a novel flexible methacrylate dressing serving as a drug delivery vehicle for antiseptics.International journal of molecular sciences · 2013Article
- Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs.International journal of nanomedicine · 2011Article
- Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO.Journal of materials science. Materials in medicine · 2009Article
- Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery.Biomaterials · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0< or = F < or = 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.