ArticleGenetics2005
Differential activation of M26-containing meiotic recombination hot spots in Schizosaccharomyces pombe.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mutual, spatially limited control of meiotic DNA break formation by Mre11-Rad50-Nbs1 DNA repair complex and Tel1 (ATM) protein kinase.Nucleic acids research · 2025Article
- Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency.PLoS genetics · 2022Article
- Intragenic meiotic recombination in Schizosaccharomyces pombe is sensitive to environmental temperature changes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Article
- Functional organization of protein determinants of meiotic DNA break hotspots.Scientific reports · 2017Article
- DNA intermediates of meiotic recombination in synchronous S. pombe at optimal temperature.Nucleic acids research · 2014Article
- DNA sequence-mediated, evolutionarily rapid redistribution of meiotic recombination hotspots.Genetics · 2011Article
- SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.Chromosoma · 2010Article
- Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe.Genetics · 2008Article
- Article
- Effects of trans-acting genetic modifiers on meiotic recombination across the a1-sh2 interval of maize.Genetics · 2006Article
- Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.Chromosoma · 2006Article
- Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identification.Genetics · 2005Article
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Authors and funding
5 authors.
Funding
Abstract
Certain genomic loci, termed hot spots, are predisposed to undergo genetic recombination during meiosis at higher levels relative to the rest of the genome. The factors that specify hot-spot potential are not well understood. The M26 hot spot of Schizosaccharomyces pombe is dependent on certain trans activators and a specific nucleotide sequence, which can function as a hot spot in a position- and orientation-independent fashion within ade6. In this report we demonstrate that a linear element (LE) component, Rec10, has a function that is required for activation of some, but not all, M26-containing hot spots and from this we propose that, with respect to hot-spot activity, there are three classes of M26-containing sequences. We demonstrate that the localized sequence context in which the M26 heptamer is embedded is a major factor governing whether or not this Rec10 function is required for full hot-spot activation. Furthermore, we show that the rec10-144 mutant, which is defective in full activation of ade6-M26, but proficient for activation of other M26-containing hot spots, is also defective in the formation of LEs, suggesting an intimate link between higher-order chromatin structure and local influences on hot-spot activation.
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Registered trials
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