ArticleJournal of bacteriology2005
Global analysis of circadian expression in the cyanobacterium Synechocystis sp. strain PCC 6803.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 148 citations in OpenAlex.
- Cyanobacterial Circadian Clock: Molecular Mechanisms and Physiological Outputs.Plants (Basel, Switzerland) · 2026Review
- Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Self-sustained rhythmic behavior ofPNAS nexus · 2025Article
- The endosymbiont ofISME communications · 2024Article
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- Phenazines as model low-midpoint potential electron shuttles for photosynthetic bioelectrochemical systems.Chemical science · 2021Article
- Time-of-day-dependent responses of cyanobacterial cellular viability against oxidative stress.Scientific reports · 2020Article
- Pooled CRISPRi screening of the cyanobacterium Synechocystis sp PCC 6803 for enhanced industrial phenotypes.Nature communications · 2020Article
- Article
- Article
- Regulatory Diversity and Functional Analysis of Two-Component Systems in CyanobacteriumFrontiers in microbiology · 2020Article
- Metatranscriptomic Analyses of Diel Metabolic Functions During aFrontiers in microbiology · 2019Article
- A diurnal flux balance model of Synechocystis sp. PCC 6803 metabolism.PLoS computational biology · 2019Article
- Daily rhythmicity in coastal microbial mats.NPJ biofilms and microbiomes · 2018Article
- Article
- Minimal tool set for a prokaryotic circadian clock.BMC evolutionary biology · 2017Article
- Role of Type 2 NAD(P)H Dehydrogenase NdbC in Redox Regulation of Carbon Allocation inPlant physiology · 2017Article
- Culturing Synechocystis sp. Strain PCC 6803 with N2 and CO2 in a Diel Regime Reveals Multiphase Glycogen Dynamics with Low Maintenance Costs.Applied and environmental microbiology · 2016Article
- Article
- Evolution of KaiC-Dependent Timekeepers: A Proto-circadian Timing Mechanism Confers Adaptive Fitness in the Purple Bacterium Rhodopseudomonas palustris.PLoS genetics · 2016Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacteria are the only bacterial species found to have a circadian clock. We used DNA microarrays to examine circadian expression patterns in the cyanobacterium Synechocystis sp. strain PCC 6803. Our analysis identified 54 (2%) and 237 (9%) genes that exhibited circadian rhythms under stringent and relaxed filtering conditions, respectively. The expression of most cycling genes peaked around the time of transition from subjective day to night, suggesting that the main role of the circadian clock in Synechocystis is to adjust the physiological state of the cell to the upcoming night environment. There were several chromosomal regions where neighboring genes were expressed with similar circadian patterns. The physiological functions of the cycling genes were diverse and included a wide variety of metabolic pathways, membrane transport, and signal transduction. Genes involved in respiration and poly(3-hydroxyalkanoate) synthesis showed coordinated circadian expression, suggesting that the regulation is important for the supply of energy and carbon source in the night. Genes involved in transcription and translation also followed circadian cycling patterns. These genes may be important for output of the rhythmic information generated by the circadian clock. Our findings provided critical insights into the importance of the circadian clock on cellular physiology and the mechanism of clock-controlled gene regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.