ArticleJournal of bacteriology2005
Transcriptome analysis of the Rhodobacter sphaeroides PpsR regulon: PpsR as a master regulator of photosystem development.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Molecular insights into the role of heme in the transcriptional regulatory system AppA/PpsR.Biophysical journal · 2022Article
- Assessment ofJournal of microbiology and biotechnology · 2021Article
- The transition of Rhodobacter sphaeroides into a microbial cell factory.Biotechnology and bioengineering · 2021Review
- An overview of anoxygenic phototrophic bacteria and their applications in environmental biotechnology for sustainable Resource recovery.Biotechnology reports (Amsterdam, Netherlands) · 2020Review
- Characterization of heterotrophic growth and sesquiterpene production by Rhodobacter sphaeroides on a defined medium.Journal of industrial microbiology & biotechnology · 2019Article
- Use of transcriptomic data for extending a model of the AppA/PpsR system in Rhodobacter sphaeroides.BMC systems biology · 2017Article
- Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.Microbiology and molecular biology reviews : MMBR · 2017Review
- Members of the PpaA/AerR Antirepressor Family Bind Cobalamin.Journal of bacteriology · 2015Article
- Gene co-expression network analysis in Rhodobacter capsulatus and application to comparative expression analysis of Rhodobacter sphaeroides.BMC genomics · 2014Article
- Article
- Analysis of the role of PrrA, PpsR, and FnrL in intracytoplasmic membrane differentiation of Rhodobacter sphaeroides 2.4.1 using transmission electron microscopy.Photosynthesis research · 2014Article
- Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Controlling the delicate balance of tetrapyrrole biosynthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- A ternary AppA-PpsR-DNA complex mediates light regulation of photosynthesis-related gene expression.Nature structural & molecular biology · 2013Article
- Interaction of two photoreceptors in the regulation of bacterial photosynthesis genes.Nucleic acids research · 2012Article
- PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein.The Journal of biological chemistry · 2012Article
- Article
- Transcriptional response of the photoheterotrophic marine bacterium Dinoroseobacter shibae to changing light regimes.The ISME journal · 2011Article
- Modeling the light- and redox-dependent interaction of PpsR/AppA in Rhodobacter sphaeroides.Biophysical journal · 2011Article
- The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
PpsR from the anoxygenic phototrophic bacterium Rhodobacter sphaeroides has been known as an oxygen- and light-dependent repressor of bacteriochlorophyll and carotenoid biosynthesis genes and puc operons involved in photosystem development. However, the putative PpsR-binding sites, TGTN12ACA, are also located upstream of numerous nonphotosystem genes, thus raising the possibility that the role of PpsR is broader. To characterize the PpsR regulon, transcriptome profiling was performed on the wild-type strain grown at high and low oxygen tensions, on the strain overproducing PpsR, and on the ppsR mutant. Transcriptome analysis showed that PpsR primarily regulates photosystem genes; the consensus PpsR binding sequence is TGTcN10gACA (lowercase letters indicate lesser conservation); the presence of two binding sites is required for repression in vivo. These findings explain why numerous single TGTN12ACA sequences are nonfunctional. In addition to photosystem genes, the hemC and hemE genes involved in the early steps of tetrapyrrole biosynthesis were identified as new direct targets of PpsR repression. Unexpectedly, PpsR was found to indirectly repress the puf and puhA operons encoding photosystem core proteins. The upstream regions of these operons contain no PpsR binding sites. Involvement in regulation of these operons suggests that PpsR functions as a master regulator of photosystem development. Upregulation of the puf and puhA operons that resulted from ppsR inactivation was sufficient to restore the ability to grow phototrophically to the prrA mutant. PrrA, the global redox-dependent activator, was previously considered indispensable for phototrophic growth. It is revealed that the PrrBA and AppA-PpsR systems, believed to work independently, in fact interact and coordinately regulate photosystem development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.