ArticleThe American journal of pathology2005
A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 90 citations in OpenAlex.
- Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects.International journal of molecular sciences · 2023Review
- Polymorphisms inArchives of endocrinology and metabolism · 2023Article
- Adaptor Protein ShcD/Molecular cancer research : MCR · 2021Article
- Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients.Rheumatology (Oxford, England) · 2020Article
- Nephroprotective Potential of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Murine Model of Chronic Cyclosporine Nephrotoxicity.Frontiers in cell and developmental biology · 2020Article
- Characterization of a Porcine Model for Von Willebrand Disease Type 1 and 3 Regarding Expression of Angiogenic Mediators in the Nonpregnant Female Reproductive Tract.Comparative medicine · 2019Article
- Vasculotide, an Angiopoietin-1 mimetic, ameliorates several features of experimental atopic dermatitis-like disease.BMC research notes · 2016Article
- Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture.The Journal of investigative dermatology · 2015Article
- Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis.Mediators of inflammation · 2015Review
- Angiogenic and inflammatory properties of psoriatic arthritis.ISRN dermatology · 2013Article
- Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and Tie2.The Journal of biological chemistry · 2011Article
- IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions.The Journal of clinical investigation · 2011Article
- Psoriasis: what we have learned from mouse models.Nature reviews. Rheumatology · 2010Review
- Evidence for altered Wnt signaling in psoriatic skin.The Journal of investigative dermatology · 2010Article
- Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture.Experimental cell research · 2009Article
- Angiogenesis drives psoriasis pathogenesis.International journal of experimental pathology · 2009Review
- Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis.The American journal of pathology · 2009Article
- Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.Nature reviews. Molecular cell biology · 2009Review
- An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.Journal of leukocyte biology · 2008Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
Abstract
Psoriasis is a common, persistent skin disorder characterized by recurrent erythematous lesions thought to arise as a result of inflammatory cell infiltration and activation of keratinocyte proliferation. Unscheduled angiogenic growth has also been proposed to mediate the pathogenesis of psoriasis although the cellular and molecular basis for this response remains unclear. Recently, a role for the angiopoietin signaling system in psoriasis has been suggested by studies that demonstrate an up-regulation of the tyrosine kinase receptor Tie2 (also known as Tek) as well as angiopoietin-1 and angiopoietin-2 in human psoriatic lesions. To examine temporal expression of Tie2, we have developed a binary transgenic approach whereby expression of Tie2 can be conditionally regulated by the presence of tetracycline analogs in double-transgenic mice. A psoriasis-like phenotype developed in double-transgenic animals within 5 days of birth and persisted throughout adulthood. The skin of affected mice exhibited many cardinal features of human psoriasis including epidermal hyperplasia, inflammatory cell accumulation, and altered dermal angiogenesis. These skin abnormalities resolved completely with tetracycline-mediated suppression of transgene expression, thereby illustrating a complete dependence on Tie2 signaling for disease maintenance and progression. Furthermore, the skin lesions in double-transgenic mice markedly improved after administration of the immunosuppressive anti-psoriatic agent cyclosporine, thus demonstrating the clinical significance of this new model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.