ArticleArthritis research & therapy2005
Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation.
Article in Arthritis research & therapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Dissecting the Immune System through Gene Regulation.Advances in experimental medicine and biology · 2024Article
- Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches.Clinical reviews in allergy & immunology · 2021Review
- Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus.Arthritis research & therapy · 2016Article
- Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice.Human gene therapy · 2013Article
- Genetics of rheumatoid arthritis - a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
- TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin.The Journal of biological chemistry · 2011Article
- Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.The American journal of pathology · 2011Article
- The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge.Arthritis research & therapy · 2011Article
- Amebic monocyte locomotion inhibitory factor peptide ameliorates inflammation in CIA mouse model by downregulation of cell adhesion, inflammation/chemotaxis, and matrix metalloproteinases genes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia.Arthritis research & therapy · 2009Article
- Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.Genes and immunity · 2008Article
- Gene expression profiling provides insights into the pathways involved in inflammatory arthritis development: murine model of Lyme disease.Experimental and molecular pathology · 2008Review
- Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model.Arthritis and rheumatism · 2007Article
- Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice.Genes and immunity · 2007Article
- Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis.Arthritis research & therapy · 2007Article
- Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model.Arthritis research & therapy · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
We present here an extensive study of differential gene expression in the initiation, acute and chronic phases of murine autoimmune arthritis with the use of high-density oligonucleotide arrays interrogating the entire mouse genome. Arthritis was induced in severe combined immunodeficient mice by using adoptive transfer of lymphocytes from proteoglycan-immunized arthritic BALB/c mice. In this unique system only proteoglycan-specific lymphocytes are transferred from arthritic mice into syngeneic immunodeficient recipients that lack adaptive immunity but have intact innate immunity on an identical (BALB/c) genetic background.Differential gene expression in response to donor lymphocytes that migrated into the joint can therefore be monitored in a precisely timed manner, even before the onset of inflammation. The initiation phase of adoptively transferred disease (several days before the onset of joint swelling) was characterized by differential expression of 37 genes, mostly related to chemokines, interferon-gamma and tumor necrosis factor-alpha signaling, and T cell functions. These were designated early arthritis 'signature' genes because they could distinguish between the naive and the pre-arthritic state. Acute joint inflammation was characterized by at least twofold overexpression of 256 genes and the downregulation of 21 genes, whereas in chronic arthritis a total of 418 genes with an equal proportion of upregulated and downregulated transcripts were expressed differentially. Hierarchical clustering and functional classification of inflammation-related and arthritis-related genes indicated that the most common biological activities were represented by genes encoding interleukins, chemokine receptors and ligands, and by those involved in antigen recognition and processing.
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Registered trials
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