ReviewWorld journal of gastroenterology2005
Regulation of apoptosis by the papillomavirus E6 oncogene.
Review in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Insights into the mechanisms and structure of breakage-fusion-bridge cycles in cervical cancer using long-read sequencing.American journal of human genetics · 2024Article
- HPV18 E6 inhibits α-ketoglutarate-induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway.FEBS open bio · 2023Article
- Transcriptomic analysis of the effects of the HPV18 E6E7 gene on the cell death mode in esophageal squamous cell carcinoma.Oncology letters · 2023Article
- Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma AcuminataAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Papillomavirus E6 oncoproteins.Virology · 2013Review
- Human Papillomavirus-mediated cervical cancer awareness and Gardasil vaccination: a pilot survey among North Indian women.Journal of community health · 2013Article
- Direct human papillomavirus E6 whole-cell enzyme-linked immunosorbent assay for objective measurement of E6 oncoproteins in cytology samples.Clinical and vaccine immunology : CVI · 2012Article
- Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.Cellular oncology (Dordrecht, Netherlands) · 2012Review
- Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis.Journal of biosciences · 2009Review
- Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins.The American journal of pathology · 2008Article
- Mitochondrial DNA mutations in human neoplasia.Journal of applied genetics · 2006Review
- Genetic predictors of cervical dysplasia in African American HIV-infected women: ACTG DACS 268.HIV clinical trialsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with human papillomaviruses is strongly associated with the development of multiple cancers including esophageal squamous cell carcinoma. The HPV E6 gene is essential for the oncogenic potential of HPV. The regulation of apoptosis by oncogene has been related to carcinogenesis closely; therefore, the modulation of E6 on cellular apoptosis has become a hot research topic recently. Inactivation of the pro-apoptotic tumor suppressor p53 by E6 is an important mechanism by which E6 promotes cell growth; it is expected that inactivation of p53 by E6 should lead to a reduction in cellular apoptosis, numerous studies showed that E6 could in fact sensitize cells to apoptosis. The molecular basis for apoptosis modulation by E6 is poorly understood. In this article, we will present an overview of observations and current understanding of molecular basis for E6-induced apoptosis.
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