ReviewPflugers Archiv : European journal of physiology2005
NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.
Review in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway.Cell death & disease · 2024Article
- Inherited Fanconi syndrome.World journal of pediatrics : WJP · 2023Review
- New Insights into the Critical Importance of Intratubular NaCurrent hypertension reports · 2021Review
- A Critical Role for NaJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Genetic and genomic evidence for an important role of the NaPhysiological genomics · 2019Review
- A novel mutation of sgk-1 gene in central serous chorioretinopathy.International journal of ophthalmology · 2015Article
- Proximal nephron.Comprehensive Physiology · 2013Review
- Article
- Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters.The Journal of biological chemistry · 2011Article
- NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.American journal of physiology. Cell physiology · 2011Article
- Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells.American journal of physiology. Cell physiology · 2011Article
- Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles.Physiological genomics · 2010Article
- BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction.The Journal of biological chemistry · 2010Article
- Enrichment of distinct microfilament-associated and GTP-binding-proteins in membrane/microvilli fractions from lymphoid cells.Journal of proteome research · 2008Article
- Emerging roles of alkali cation/proton exchangers in organellar homeostasis.Current opinion in cell biology · 2007Review
- Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea.Cell and tissue research · 2006Article
- Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia: role in apical retention and targeting.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The sodium-hydrogen exchanger 3 (NHE3) isoform is the major regulated sodium transporter in the proximal convoluted tubule of the kidney. Study of the regulation of NHE3 by hormonal stimuli has identified a number of PDZ adaptor proteins that form an apical/subapical membrane scaffold that binds NHE3 and facilitates down-regulation of its activity in response to cAMP and activation of protein kinase A. The precise relation of proximal tubule adaptor proteins such as sodium-hydrogen exchanger regulatory factor-1 (NHERF-1), NHERF-2, and PDZ domain-containing-protein-1 (PDZK1) with each other and with protein targets such as NHE3 has been evolving with the development of specific reagents and genetically altered animals. In this review, we trace the discovery of NHERF-1 and NHERF-2, and update our current understanding of the relation between these proteins and the regulation and trafficking of NHE3.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.