ArticleJournal of clinical immunology2005
The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis.
Article in Journal of clinical immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
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- Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy.Biomolecules · 2023Article
- Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers.Frontiers in immunology · 2023Article
- Immunohistochemical Analysis of Postburn Scars following Treatment Using Dermal Substitutes.Analytical cellular pathology (Amsterdam) · 2022Article
- Prenatal intake of omega-3 promotes Wnt/β-catenin signaling pathway, and preserves integrity of the blood-brain barrier in preeclamptic rats.Physiological reports · 2021Article
- Review
- Where the Action Is-Leukocyte Recruitment in Atherosclerosis.Frontiers in cardiovascular medicine · 2021Review
- PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.Frontiers in immunology · 2019Article
- T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy.JCI insight · 2018Article
- Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacteriumOncotarget · 2017Article
- Decreased frequencies and impaired functions of the CD31Clinical and experimental immunology · 2017Article
- Non-pathogenic tissue-resident CD8Scientific reports · 2017Article
- Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?Nature reviews. Rheumatology · 2016Review
- The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.Science signaling · 2016Article
- Role of PECAM-1 in radiation-induced liver inflammation.Journal of cellular and molecular medicine · 2015Article
- Preeclampsia does not alter vascular growth and expression of CD31 and vascular endothelial cadherin in human placentas.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- PECAM-1 gene polymorphisms and soluble PECAM-1 level in rheumatoid arthritis and systemic lupus erythematosus patients: any link with clinical atherosclerotic events?Clinical rheumatology · 2014Article
- CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of PECAM-1(-/-) mice have identified that PECAM-1 functions as an inhibitory co-receptor to modulate immunological responsiveness. In this study, we describe the in vivo consequences of PECAM-1 deficiency in mouse models of collagen-induced arthritis (CIA) and K/BxN passive transfer model that resembles many of the features of human rheumatoid arthritis. Immunization of PECAM-1(-/-) C57BL/6 (H-2b) mice with chicken collagen type II induced CIA with an incidence of 82% by day 49, while 33%; of wild-type and 100% of DBA/1 mice developed arthritis in a similar time frame. The mean onset of disease for PECAM-1(-/-) C57BL/6 mice was day 32 compared to day 51 for wild-type C57BL/6 mice and day 18 for DBA/1 mice (H-2q susceptible). In terms of disease severity, the mean maximal arthritic index for PECAM-1(-/-) C57BL/6 mice was comparable to DBA/1 mice (8.91 +/- 0.91 vs 11.67 +/- 0.82). This mean maximal index in PECAM-1(-/-) C57BL/6 mice was significantly higher than wild-type C57BL/6 mice (5.00 +/- 0.73). IgG1 and IgG2b antibody responses against CII were elevated in arthritic PECAM-1(-/-) C57BL/6 mice compared to wild-type C57BL/6 mice. Histological examination of arthritic paws of PECAM-1(-/-) C57BL/6 mice revealed inflammatory infiltrates of lymphocytic/monocytic cells and cartilage/bone destruction similar to CIA-induced DBA/1 arthritic paws. In the K/BxN model, the arthritis was not augmented in PECAM-1(-/-) mice compared to wild-type mice. In contrast, in active CIA, PECAM-1(-/-) mice developed severe disease comparable to susceptible DBA/1 mice and profoundly more severe than C57BL/6 mice, where only one third developed a mild/moderate disease. Together these observations suggest that PECAM-1 plays a crucial role in the suppression of development of autoimmune arthritis.
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