ArticleJournal of neurology2005
Generalized myositis mimicking polymyositis associated with chronic active Epstein-Barr virus infection.
Article in Journal of neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Multisystem T-cell Chronic Active Epstein-Barr Virus Infection: From the Eye to the Kidney.Open forum infectious diseases · 2022Article
- Epstein-Barr virus infection associated polymyositis and coronary artery dilation.BMC infectious diseases · 2022Article
- Peculiar histological and ultrastructural skeletal muscle alterations in a patient with CMV infection and autoimmune myositis: case evaluation and brief literature review.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2022Article
- Case report: Systemic muscle involvement as the primary clinical manifestation of chronic active Epstein-Barr virus infection: A case-based review.Frontiers in immunology · 2022Article
- X-Linked Dilated Cardiomyopathy Presenting as Acute Rhabdomyolysis and Presumed Epstein-Barr Virus-Induced Viral Myocarditis: A Case Report.The American journal of case reports · 2018Article
- Differential diagnosis of idiopathic inflammatory myopathies in adults - the first step when approaching a patient with muscle weakness.Reumatologia · 2018Review
- Lymphomatoid Granulomatosis with Paraneoplastic Polymyositis: A Rare Malignancy with Rare Complication.Case reports in rheumatology · 2016Article
- SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Rash and elevated creatine kinase in a deployed soldier.Military medicine · 2014Article
- EBV-Positive T/NK-Cell Lymphoproliferative Disease of Childhood.Korean journal of pathology · 2013Article
- Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis.International journal of hematology · 2011Article
- Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan.Arthritis research & therapy · 2010Article
- Recurrent myositis triggered by infections: a case report.Journal of medical case reports · 2008Article
- Bacterial, fungal, parasitic, and viral myositis.Clinical microbiology reviews · 2008Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic generalized myositis has not so far been reported as a complication of chronic active Epstein-Barr virus infection (CAEBV). We encountered three patients with chronic generalized myositis mimicking polymyositis associated with CAEBV.
methodsTo clarify the pathological character of this myositis, we investigated the distribution, clonality, and the immunophenotype of EBV-infected cells and lymphocytes infiltrating in muscles.
resultsClinically, two patients showed symmetrical proximal weakness and muscle atrophy as the initial and main symptom. Although the condition resembled polymyositis, they had also lingual and/or orbital myositis. The other patient showed generalized myositis at the late phase of CAEBV. In all of them, immunotherapy was ineffective and prognosis was poor. Intramuscular infiltrating lymphocytes in our patients were mainly CD45RO+, CD3+, CD4-, CD8-, TCR betaF1-, TCR deltaTCS1-, CD56-, CD79a-, CD21-, HLA-DR+, ZEBRA -, LMP1-, and EBER+ T cells. Oligoclonal expansion of EBV-infected T cells was shown in the muscles. However, there were no malignant lymphocytes.
conclusionsThis new form of myositis must be distinguished from polymyositis and the other conventional forms of myositis. Careful investigation of hidden CAEBV is recommended when patients present with steroid non-responsive chronic progressive generalized myositis, in particular, with lingual or orbital involvement.
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