ArticleChemical senses2005
A method for the rapid automated assessment of olfactory function.
Article in Chemical senses, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Deficits in olfactory sensitivity in a mouse model of Parkinson's disease revealed by plethysmography of odor-evoked sniffing.Scientific reports · 2020Article
- Young and middle-aged mouse breathing behavior during the light and dark cycles.Physiological reports · 2019Article
- Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex.Brain structure & function · 2019Article
- The Interaction of Ethanol Ingestion and Social Interaction with an Intoxicated Peer on the Odor-Mediated Response to the Drug in Adolescent Rats.Alcoholism, clinical and experimental research · 2016Article
- Minimally invasive highly precise monitoring of respiratory rhythm in the mouse using an epithelial temperature probe.Journal of neuroscience methods · 2016Article
- Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice.Neural plasticity · 2016Article
- Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats.PloS one · 2014Article
- Fetal nicotine exposure increases preference for nicotine odor in early postnatal and adolescent, but not adult, rats.PloS one · 2013Article
- Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol.Experimental biology and medicine (Maywood, N.J.) · 2012Article
- The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats.Alcoholism, clinical and experimental research · 2010Article
- Ontogeny of the enhanced fetal-ethanol-induced behavioral and neurophysiologic olfactory response to ethanol odor.Alcoholism, clinical and experimental research · 2010Article
- Adolescent ethanol experience alters immediate and long-term behavioral responses to ethanol odor in observer and demonstrator rats.Behavioral and brain functions : BBF · 2009Article
- Fetal ethanol exposure increases ethanol intake by making it smell and taste better.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats.Brain research · 2009Article
- Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat.Journal of neurophysiology · 2009Article
- The consequence of fetal ethanol exposure and adolescent odor re-exposure on the response to ethanol odor in adolescent and adult rats.Behavioral and brain functions : BBF · 2009Article
- A method for generating natural and user-defined sniffing patterns in anesthetized or reduced preparations.Chemical senses · 2009Article
- Sniffing behavior of mice during performance in odor-guided tasks.Chemical senses · 2008Article
- Sexually dimorphic enhancement by estradiol of male urinary odor detection thresholds in mice.Behavioral neuroscience · 2008Article
- Experience-induced fetal plasticity: the effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats.Behavioral neuroscience · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
We have developed a strategy for the rapid high-throughput screening of odor responsivity in genetically altered mice (in fact, any experimentally altered animal). Specifically, the report presents the development and validation of a fully automated procedure based on the evaluation of an animal's stimulus-induced reflexive breathing response (i.e. sniffing behavior) to both air and odorant stimuli. The method requires no training of the animal to be screened and the outcome of the evaluation yields an operationally defined measure. Briefly, using whole-body plethysmography, the procedure determines the numerical values for a set of 14 respiratory measures in response to the presentation of air and a well-above-threshold concentration of the odorant propanol. These measures of stimulus-induced sniffing are incorporated into a model that defines a single univariate measure of response behavior, or 'Sniffing Index', for each screened animal. The approach significantly discriminated between the reflexive sniffing response of a control group of mice and that of an experimentally defined manipulated group for which, a priori, we expected to observe a robust altered breathing response to odorant stimulation (i.e. non-odor-aversion-conditioned versus odor-aversion-conditioned C57BL/6J mice). Further, the procedure was able to significantly discriminate between a mutant phenotype with documented alterations in physiologic and behavioral function (namely, the OMP-null mutant), and their background strain. In addition, applying epidemiologic screening principles to the observed data, we established an operational procedure for the evaluation of unknown animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.