ArticleGenome research2005
Database of mRNA gene expression profiles of multiple human organs.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Transcriptional assessment by microarray analysis and large-scale meta-analysis of the metabolic capacity of cardiac and skeletal muscle tissues to cope with reduced nutrient availability in Gilthead Sea Bream (Sparus aurata L.).Marine biotechnology (New York, N.Y.) · 2014Pooled it
- Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010Pooled it
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- Next-generation muscle-directed gene therapy by in silico vector design.Nature communications · 2019Article
- Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse Model.International journal of molecular sciences · 2018Article
- Pan-organ transcriptome variation across 21 cancer types.Oncotarget · 2017Article
- Paired Expression Analysis of Tumor Cell Surface Antigens.Frontiers in oncology · 2017Article
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- ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells.Nucleic acids research · 2016Article
- Algorithms for modeling global and context-specific functional relationship networks.Briefings in bioinformatics · 2016Article
- Gene Expression Profiling Reveals Functional Specialization along the Intestinal Tract of a Carnivorous Teleostean Fish (Dicentrarchus labrax).Frontiers in physiology · 2016Article
- MIsoMine: a genome-scale high-resolution data portal of expression, function and networks at the splice isoform level in the mouse.Database : the journal of biological databases and curation · 2015Article
- Liver-specific transcriptional modules identified by genome-wide in silico analysis enable efficient gene therapy in mice and non-human primates.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.Trends in genetics : TIG · 2014Review
- A novel method for identification and quantification of consistently differentially methylated regions.PloS one · 2014Article
- Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer.PloS one · 2013Article
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Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Genome-wide expression profiling of normal tissue may facilitate our understanding of the etiology of diseased organs and augment the development of new targeted therapeutics. Here, we have developed a high-density gene expression database of 18,927 unique genes for 158 normal human samples from 19 different organs of 30 different individuals using DNA microarrays. We report four main findings. First, despite very diverse sample parameters (e.g., age, ethnicity, sex, and postmortem interval), the expression profiles belonging to the same organs cluster together, demonstrating internal stability of the database. Second, the gene expression profiles reflect major organ-specific functions on the molecular level, indicating consistency of our database with known biology. Third, we demonstrate that any small (i.e., n approximately 100), randomly selected subset of genes can approximately reproduce the hierarchical clustering of the full data set, suggesting that the observed differential expression of >90% of the probed genes is of biological origin. Fourth, we demonstrate a potential application of this database to cancer research by identifying 19 tumor-specific genes in neuroblastoma. The selected genes are relatively underexpressed in all of the organs examined and belong to therapeutically relevant pathways, making them potential novel diagnostic markers and targets for therapy. We expect this database will be of utility for developing rationally designed molecularly targeted therapeutics in diseases such as cancer, as well as for exploring the functions of genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.