ArticleGenome research2005
Computational analysis of 3'-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 124 citations in OpenAlex.
- Deciphering Estrus Expression in Gilts: The Role of Alternative Polyadenylation and LincRNAs in Reproductive Transcriptomics.Animals : an open access journal from MDPI · 2024Article
- Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter.Developmental cell · 2022Article
- Article
- Alternative splicing and translation play important roles in hypoxic germination in rice.Journal of experimental botany · 2019Article
- Omni-PolyA: a method and tool for accurate recognition of Poly(A) signals in human genomic DNA.BMC genomics · 2017Article
- Analyses of alternative polyadenylation: from old school biochemistry to high-throughput technologies.BMB reports · 2017Review
- Processing and transcriptome expansion at the mRNA 3' end in health and disease: finding the right end.Pflugers Archiv : European journal of physiology · 2016Review
- CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function.RNA (New York, N.Y.) · 2016Article
- New frontiers in translational control of the cancer genome.Nature reviews. Cancer · 2016Review
- Genome-wide determination of poly(A) sites in Medicago truncatula: evolutionary conservation of alternative poly(A) site choice.BMC genomics · 2014Article
- Microarray meta-analysis of RNA-binding protein functions in alternative polyadenylation.PloS one · 2014Article
- 3'LIFE: a functional assay to detect miRNA targets in high-throughput.Nucleic acids research · 2014Article
- Genome-wide analysis of poly(A) site selection in Schizosaccharomyces pombe.RNA (New York, N.Y.) · 2013Article
- DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast.Genome research · 2013Article
- Alterations in polyadenylation and its implications for endocrine disease.Frontiers in endocrinology · 2013Article
- Alternative polyadenylation: new insights from global analyses.RNA (New York, N.Y.) · 2012Review
- Plant polyadenylation factors: conservation and variety in the polyadenylation complex in plants.BMC genomics · 2012Article
- Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance.Genome research · 2012Article
- Regulation of cytoplasmic mRNA decay.Nature reviews. Genetics · 2012Review
- Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alternative initiation, splicing, and polyadenylation are key mechanisms used by many organisms to generate diversity among mature mRNA transcripts originating from the same transcription unit. While previous computational analyses of alternative polyadenylation have focused on polyadenylation activities within or downstream of the normal 3'-terminal exons, we present the results of the first genome-wide analysis of patterns of alternative polyadenylation in the human, mouse, and rat genomes occurring over the entire transcribed regions of mRNAs using 3'-ESTs with poly(A) tails aligned to genomic sequences. Four distinct classes of patterns of alternative polyadenylation result from this analysis: tandem poly(A) sites, composite exons, hidden exons, and truncated exons. We estimate that at least 49% (human), 31% (mouse), and 28% (rat) of polyadenylated transcription units have alternative polyadenylation. A portion of these alternative polyadenylation events result in new protein isoforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.