ArticleJournal of cell science2005
Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2.
Article in Journal of cell science, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 0 citations in OpenAlex.
- Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.PLoS biology · 2008Trial
- C-Terminal Extended Domain-Independent Telomere Maintenance: Modeling the Function of TIN2 Isoforms inInternational journal of molecular sciences · 2025Article
- Review
- SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling.Science signaling · 2021Article
- Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.Nature communications · 2019Article
- Back to the future: The intimate and evolving connection between telomere-related factors and genotoxic stress.The Journal of biological chemistry · 2019Review
- A Functionally Robust Phenotypic Screen that Identifies Drug Resistance-associated Genes Using 3D Cell Culture.Bio-protocol · 2018Article
- Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin.Cell cycle (Georgetown, Tex.) · 2016Article
- Three-dimensional culture of human breast epithelial cells: the how and the why.Methods in molecular biology (Clifton, N.J.) · 2013Article
- TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase.The Journal of biological chemistry · 2011Article
- Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.Molecular & cellular proteomics : MCP · 2011Article
- Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors.PloS one · 2011Article
- Laminin regulates PI3K basal localization and activation to sustain STAT5 activation.Cell cycle (Georgetown, Tex.) · 2010Article
- Statistical analysis of 3D images detects regular spatial distributions of centromeres and chromocenters in animal and plant nuclei.PLoS computational biology · 2010Article
- Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell.Journal of mammary gland biology and neoplasia · 2010Review
- Gene expression in the third dimension: the ECM-nucleus connection.Journal of mammary gland biology and neoplasia · 2010Review
- Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.The Journal of cell biology · 2009Article
- Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices.Cancer metastasis reviews · 2009Review
- Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.Molecular biology of the cell · 2009Article
- A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix.Cell cycle (Georgetown, Tex.) · 2009Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Nuclear organization, such as the formation of specific nuclear subdomains, is generally thought to be involved in the control of cellular phenotype; however, there are relatively few specific examples of how mammalian nuclei organize during radical changes in phenotype, such as those occurring during differentiation and growth arrest. Using human mammary epithelial cells in which growth arrest is essential for morphological differentiation, we show that the arrest of cell proliferation is accompanied by a reorganization of the telomere-associated protein, TIN2, into one to three large nuclear subdomains. The large TIN2 domains do not contain telomeres and occur concomitant with the continued presence of TIN2 at telomeres. The TIN2 domains were sensitive to DNase, but not RNase, occurred frequently, but not exclusively near nucleoli, and overlapped often with dense domains containing heterochromatin protein 1gamma. Expression of truncated forms of TIN2 simultaneously prevented the formation of TIN2 domains and relaxed the stringent morphogenesis-induced growth arrest in human mammary epithelial cells. Here we show that a novel extra-telomeric organization of TIN2 is associated with the control of cell proliferation and identify TIN2 as an important regulator of mammary epithelial differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.