ArticleBMC cancer2005
Age and manifestation related symptoms in familial adenomatous polyposis.
Article in BMC cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Challenging Aspects of Familial Adenomatous Polyposis With Malignant Transformation: A Report of Two Cases.Cureus · 2025Article
- A Closer Look: Familial Adenomatous Polyposis Suspected Through Ophthalmological Findings in an Adolescent.Cureus · 2025Article
- Endoscopic Surveillance after (Procto)Colectomy with Gastrointestinal Reconstruction in Patients with Familial Adenomatous Polyposis (FAP)-Principles, Goals and Practical Aspects Based on 12 Years of Observation.Life (Basel, Switzerland) · 2024Article
- Use of congenital hypertrophy of the retinal pigment epithelium as a clinical sign of familial adenomatous polyposis.Arquivos brasileiros de oftalmologia · 2024Article
- Review
- Familial Adenomatous Polyposis (FAP) Presenting as Iron Deficiency Anemia in a 33-Year-Old Female: A Case Report.Cureus · 2022Article
- Genetic cancer predisposition syndromes among older adults.Journal of geriatric oncology · 2020Review
- Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients.International journal of tryptophan research : IJTR · 2019Article
- Genetically engineered pigs as models for human disease.Disease models & mechanisms · 2018Review
- Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis.Oncotarget · 2017Article
- Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.Scientific reports · 2017Article
- [Surgical aspects of indications and techniques for adenomatous polyposis variants].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Review
- Surgical considerations in FAP-related pouch surgery: Could we do better?Familial cancer · 2016Review
- Bloating and functional gastro-intestinal disorders: where are we and where are we going?World journal of gastroenterology · 2014Review
- How harmful is genetic testing for familial adenomatous polyposis (FAP) in young children; the parents' experience.Familial cancer · 2014Article
- Genetically modified pigs to model human diseases.Journal of applied genetics · 2014Review
- The new pig on the block: modelling cancer in pigs.Transgenic research · 2013Review
- Evaluating causes of death in familial adenomatous polyposis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- Parental attitudes, beliefs, and perceptions about genetic testing for FAP and colorectal cancer surveillance in minors.Journal of genetic counseling · 2010Article
- Colorectal cancer in the course of familial adenomatous polyposis syndrome ("de novo" pathogenic mutation of APC gene): case report, review of the literature and genetic commentary.Archives of medical science : AMS · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo identify early symptoms of familial adenomatous polyposis with a view to improve early diagnosis and treatment. Diagnosis on the basis of genetic testing is usually limited to where there is a known family history, so FAP is more usually diagnosed on clinical grounds. Except for those identified via FAP registers, the majority of patients are symptomatic at the time of diagnosis.
methodsWe undertook a retrospective study of 143 FAP patients treated at the Department of Surgery, University of Erlangen between 1971 and 2000. We identified patterns of symptoms, endoscopic findings and extracolonic manifestations in three age groups.
resultsFAP was diagnosed clinically on the basis of symptoms in 84% (120/143) of these patients. Most presented with intestinal symptoms such as colonic bleeding (68%) and diarrhea (42%). All but one of the patients between 20 and 40 years old had rectal polyps (98.7%, 75/76), whereas in those over 40 years old the prevalence was 76% (35/46). Non-specific symptoms such as abdominal pain, fatigue and bloating were less frequent and were mainly reported by patients older than 40.
conclusionThe commonest presenting features of FAP are alteration of bowel habit and rectal bleeding, but both are found in many other conditions. Patients with these findings need immediate endoscopy to allow prompt diagnosis and prophylactic surgery.
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