ArticleBMC genetics2005
Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2.
Article in BMC genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
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- Distinct Roles for Two Chromosome 1 Loci in Ethanol Withdrawal, Consumption, and Conditioned Place Preference.Frontiers in genetics · 2018Article
- Neuroepigenetics and addiction.Handbook of clinical neurology · 2018Review
- Addiction resistance: Definition, validation and association with mastery.Drug and alcohol dependence · 2015Article
- Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence.Molecular psychiatry · 2012Article
- ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.Chinese medical journal · 2012Article
- Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study.BMC genomics · 2012Article
- Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder.Psychiatric genetics · 2011Article
- Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study.Drug and alcohol dependence · 2011Article
- A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.Addiction biology · 2010Review
- Article
- Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence.Journal of neurogenetics · 2009Review
- Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.Annals of the New York Academy of Sciences · 2008Review
- The genomic determinants of alcohol preference in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.Molecular psychiatry · 2008Article
- "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.Biochemical pharmacology · 2008Review
- Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4.Molecular psychiatry · 2006Article
- Genomic screen for loci associated with tobacco usage in Mission Indians.BMC medical genetics · 2006Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study.
methodsDNA from eighteen families, densely affected by alcoholism, was used to genotype a set of polymorphic microsatellite markers at loci approximately 10 centimorgans apart spanning the short arm and part of the long arm of chromosome 1. Linkage analyses were performed using the classical lod score and a model-free method. Three different definitions of affection status were defined, these were 1. Heavy Drinking (HD) where affected subjects drank more than the Royal College of Psychiatrists recommended weekly amount. 2. The Research Diagnostic Criteria for alcoholism (RDCA) 3. Alcohol Dependence Syndrome (ADS) as defined by Edwards and Gross (1976) and now incorporated into ICD10 and DSMIV.
resultsLinkage analyses with the markers D1S1588, D1S2134, D1S1675 covering the cytogenetic region 1p22.1-11.2 all gave positive two point and multipoint lods with a maximum lod of 1.8 at D1S1588 (1p22.1) for the RDCA definition of alcoholism. Another lod of 1.8 was found with D1S1653 in the region 1q21.3-24.2 using the HD affection model.
conclusionThese results both support the presence of linkage in the 1p22.1-11.2 region which was previously implicated by the USA Collaborative Study of the Genetics of Alcoholism (COGA) study and also suggest the presence of another susceptibility locus at 1q21.3-24.2.
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