ArticleTissue engineering
Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectin.
Article in Tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 68 citations in OpenAlex.
- Promising Novel Therapies in the Treatment of Aortic and Visceral Aneurysms.Journal of clinical medicine · 2023Review
- Application of mesenchymal stem cells combined with nano-polypeptide hydrogel in tissue engineering blood vessel.Regenerative therapy · 2022Review
- Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel.Frontiers in bioengineering and biotechnology · 2021Review
- Tissue Engineered Esophageal Patch by Mesenchymal Stromal Cells: Optimization of Electrospun Patch Engineering.International journal of molecular sciences · 2020Article
- Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts.Frontiers in bioengineering and biotechnology · 2020Article
- Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.Cell stem cell · 2018Review
- Acute Swine Model for Assessing Biocompatibility of Biomedical Interface Materials.Tissue engineering. Part C, Methods · 2018Article
- Implants in bone: part I. A current overview about tissue response, surface modifications and future perspectives.Oral and maxillofacial surgery · 2014Review
- Two-stage implantation of the skin- and bone-integrated pylon seeded with autologous fibroblasts induced into osteoblast differentiation for direct skeletal attachment of limb prostheses.Journal of biomedical materials research. Part A · 2014Article
- QHREDGS enhances tube formation, metabolism and survival of endothelial cells in collagen-chitosan hydrogels.PloS one · 2013Article
- Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.Journal of healthcare engineering · 2012Article
- Biocompatible and bioactive surface modifications for prolonged in vivo efficacy.Chemical reviews · 2012Review
- Advantages of RGD peptides for directing cell association with biomaterials.Biomaterials · 2011Article
- Cell-seeding techniques in vascular tissue engineering.Tissue engineering. Part B, Reviews · 2010Review
- The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype.Biomaterials · 2009Article
- Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion.Journal of the American Chemical Society · 2008Article
- Introduction. Bioengineering the heart.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Biomimetic materials that mimic the extracellular matrix (ECM) provide a means to control cellular functions such as adhesion and growth, which are vital to successful engineering of tissue-incorporated biomaterials. Novel "ECM-like" biomimetic surfactant polymers consisting of a poly(vinyl amine) backbone with pendant cell-adhesive peptides derived from one of the heparin-binding domains of fibronectin were developed to improve endothelial cell adhesion and growth on vascular biomaterials. Heparin-binding peptide (HBP) sequences, alone and in combination with RGD peptides, were examined for their ability to promote human pulmonary artery endothelial cell (HPAEC) adhesion and growth (HBP1, WQPPRARI; HBP2, SPPRRARVT; HBP1:RGD; and HBP2:RGD) and compared with cell adhesion and growth on fibronectin and on negative control polymer surfaces in which alanines were substituted for the positively charged arginine residues in the two peptides. The results showed that HPAECs adhered and spread equally well on all HBP-containing polymers and the positive fibronectin control, showing similar stress fiber and focal adhesion formation. However, the HBP alone was unable to support long-term HPAEC growth and survival, showing a loss of focal adhesions and cytoskeletal disorganization by 24 h after seeding. With the addition of RGD, the surfaces behaved similarly or better than fibronectin. The negative control polymers showed little to no initial cell attachment, and the addition of soluble heparin to the medium reduced initial cell adhesion on both the HBP2 and HBP2:RGD surfaces. These results indicate that the HBP surfaces promote initial HPAEC adhesion and spreading, but not long-term survival.
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