ArticleThe Journal of cell biology2005
Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Candida glabrata YPK2 is a multidrug susceptibility locus.Genetics · 2026Article
- Article
- The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system.Brain pathology (Zurich, Switzerland) · 2026Review
- Determinants of Peroxisome Membrane Dynamics.Frontiers in physiology · 2022Review
- Molecular Basis of Mitochondrial and Peroxisomal Division Machineries.International journal of molecular sciences · 2020Review
- Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- Sphingolipids and lipid rafts: Novel concepts and methods of analysis.Chemistry and physics of lipids · 2018Review
- A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins.PLoS pathogens · 2014Article
- Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes.Frontiers in physiology · 2013Review
- Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration.Frontiers in physiology · 2012Article
- Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes.Molecular biology of the cell · 2010Article
- Peroxisome matrix and membrane protein biogenesis.IUBMB life · 2009Review
- Genome-wide analysis of signaling networks regulating fatty acid-induced gene expression and organelle biogenesis.The Journal of cell biology · 2008Article
- Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.Genes & development · 2008Article
- A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane.The Journal of cell biology · 2007Article
- Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER.The Journal of cell biology · 2006Review
- Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles.Molecular biology of the cell · 2005Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe unusual ergosterol- and ceramide-rich (ECR) domains in the membrane of yeast peroxisomes. Several key features of these detergent-resistant domains, including the nature of their sphingolipid constituent and its unusual distribution across the membrane bilayer, clearly distinguish them from well characterized detergent-insoluble lipid rafts in the plasma membrane. A distinct set of peroxisomal proteins, including two ATPases, Pex1p and Pex6p, as well as phosphoinositide- and GTP-binding proteins, transiently associates with the cytosolic face of ECR domains. All of these proteins are essential for the fusion of the immature peroxisomal vesicles P1 and P2, the earliest intermediates in a multistep pathway leading to the formation of mature, metabolically active peroxisomes. Peroxisome fusion depends on the lateral movement of Pex1p, Pex6p, and phosphatidylinositol-4,5-bisphosphate-binding proteins from ECR domains to a detergent-soluble portion of the membrane, followed by their release to the cytosol. Our data suggest a model for the multistep reorganization of the multicomponent peroxisome fusion machinery that transiently associates with ECR domains.
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