ArticlePLoS biology2005
Recombination every day: abundant recombination in a virus during a single multi-cellular host infection.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 135 citations in OpenAlex.
- Novel genetic variants of banana streak MY virus and banana streak IM virus naturally infecting banana in Northeast India.3 Biotech · 2024Article
- Identification and Full Genome Analysis of the First Putative Virus of Sea Buckthorn (Microorganisms · 2022Article
- Members of the ribosomal protein S6 (RPS6) family act as pro-viral factor for tomato spotted wilt orthotospovirus infectivity in Nicotiana benthamiana.Molecular plant pathology · 2022Article
- The recombinogenic history of turnip mosaic potyvirus reveals its introduction to Japan in the 19th century.Virus evolution · 2022Article
- Genome-wide identification of Reverse Transcriptase domains of recently inserted endogenous plant pararetrovirus (Frontiers in plant science · 2022Article
- Article
- Intra-Colonial Viral Infections in Western Honey Bees (Microorganisms · 2021Article
- Participation of Multifunctional RNA in Replication, Recombination and Regulation of Endogenous Plant Pararetroviruses (EPRVs).Frontiers in plant science · 2021Review
- Orthohantaviruses, Emerging Zoonotic Pathogens.Pathogens (Basel, Switzerland) · 2020Review
- Pervasive within-host recombination and epistasis as major determinants of the molecular evolution of the foot-and-mouth disease virus capsid.PLoS pathogens · 2020Article
- In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV-2 genomic data.The Pan African medical journal · 2020Article
- Detection of Plant Viruses and Disease Management: Relevance of Genetic Diversity and Evolution.Frontiers in plant science · 2020Review
- Article
- Article
- Impact of Cultivated Hosts on the Recombination ofJournal of virology · 2019Article
- Positive selection and recombination shaped the large genetic differentiation of Beet black scorch virus population.PloS one · 2019Article
- Genetic diversity and molecular evolution ofPeerJ · 2018Article
- Time-Sampled Population Sequencing Reveals the Interplay of Selection and Genetic Drift in Experimental Evolution ofJournal of virology · 2017Article
- Genomic fossils reveal adaptation of non-autonomous pararetroviruses driven by concerted evolution of noncoding regulatory sequences.PLoS pathogens · 2017Article
- Evolutionary ecology of virus emergence.Annals of the New York Academy of Sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral recombination can dramatically impact evolution and epidemiology. In viruses, the recombination rate depends on the frequency of genetic exchange between different viral genomes within an infected host cell and on the frequency at which such co-infections occur. While the recombination rate has been recently evaluated in experimentally co-infected cell cultures for several viruses, direct quantification at the most biologically significant level, that of a host infection, is still lacking. This study fills this gap using the cauliflower mosaic virus as a model. We distributed four neutral markers along the viral genome, and co-inoculated host plants with marker-containing and wild-type viruses. The frequency of recombinant genomes was evaluated 21 d post-inoculation. On average, over 50% of viral genomes recovered after a single host infection were recombinants, clearly indicating that recombination is very frequent in this virus. Estimates of the recombination rate show that all regions of the genome are equally affected by this process. Assuming that ten viral replication cycles occurred during our experiment-based on data on the timing of coat protein detection-the per base and replication cycle recombination rate was on the order of 2 x 10(-5) to 4 x 10(-5). This first determination of a virus recombination rate during a single multi-cellular host infection indicates that recombination is very frequent in the everyday life of this virus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.