ArticleInternational journal of legal medicine2005
Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis.
Article in International journal of legal medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Anaphylactic deaths: A retrospective study of forensic autopsy cases from 2009 to 2019 in Shanghai, China.Heliyon · 2024Article
- Secretory and Membrane-Associated Biomarkers of Mast Cell Activation and Proliferation.International journal of molecular sciences · 2023Review
- A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.Science immunology · 2023Article
- New Biomarkers in Anaphylaxis (Beyond Tryptase).Current treatment options in allergy · 2022Review
- State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics.Life (Basel, Switzerland) · 2021Review
- Interference of hemolysis on the postmortem biochemical analysis of IgE by ECLIA.International journal of legal medicine · 2021Article
- Anaphylactic Death: A New Forensic Workflow for Diagnosis.Healthcare (Basel, Switzerland) · 2021Article
- Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue.The Journal of surgical research · 2020Article
- Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease.Translational andrology and urology · 2019Review
- Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.Frontiers in immunology · 2019Review
- IgE-Mediated Systemic Anaphylaxis And Its Association With Gene Polymorphisms Of ACE, Angiotensinogen And Chymase.Journal of asthma and allergy · 2019Article
- Identification of pulmonary edema in forensic autopsy cases of fatal anaphylactic shock using Fourier transform infrared microspectroscopy.International journal of legal medicine · 2018Article
- Mast cell tryptase and carboxypeptidase A expression in body fluid and gastrointestinal tract associated with drug-related fatal anaphylaxis.World journal of gastroenterology · 2015Article
- Splenic hypereosinophilia in anaphylaxis-related death: different assessments depending on different types of allergens?International journal of legal medicine · 2015Article
- Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms.International journal of legal medicine · 2014Review
- Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity.Seminars in immunopathology · 2012Article
- Postmortem chemistry update part II.International journal of legal medicine · 2012Review
- Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chymase, a serine protease, is stored mainly in secretory granules of human mast cells. Serum chymase concentration was examined in 8 autopsy cases with anaphylaxis as well as in 104 control cases without anaphylaxis. It was detected in all 8 cases with anaphylaxis (range 3-380 ng/ml, mean 89.8 ng/ml), while it was detected in only 2 of the 104 controls and was below a detectable level (<3 ng/ml) in the other 102. Serum tryptase levels are known to be a diagnostic indicator of anaphylaxis, therefore the relationship between serum chymase and tryptase levels was investigated in the 8 cases of anaphylactic death; a significant positive correlation was found (r=0.826, p=0.011). Furthermore, chymase was shown to be quite stable in serum. These results showed that measurement of serum chymase levels might be an additional tool for postmortem diagnosis of anaphylaxis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.