ArticleJournal of the Association for Research in Otolaryngology : JARO2005
Disruption of lateral olivocochlear neurons via a dopaminergic neurotoxin depresses sound-evoked auditory nerve activity.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Audiological biomarkers of tinnitus in an older Portuguese population.Frontiers in aging neuroscience · 2022Article
- Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity.Frontiers in cell and developmental biology · 2021Article
- Article
- Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.The Journal of the Acoustical Society of America · 2019Review
- Isoflurane anesthesia suppresses distortion product otoacoustic emissions in rats.Journal of otology · 2018Article
- Contralateral Inhibition of Click- and Chirp-Evoked Human Compound Action Potentials.Frontiers in neuroscience · 2017Article
- Stochastic Resonance Controlled Upregulation of Internal Noise after Hearing Loss as a Putative Cause of Tinnitus-Related Neuronal Hyperactivity.Frontiers in neuroscience · 2016Article
- Dopamine Modulates the Activity of Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Disruption of lateral olivocochlear neurons with a dopaminergic neurotoxin depresses spontaneous auditory nerve activity.Neuroscience letters · 2014Article
- Dynorphin release by the lateral olivocochlear efferents may inhibit auditory nerve activity: a cochlear drug delivery study.Neuroscience letters · 2014Article
- Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Efferent synapses return to inner hair cells in the aging cochlea.Neurobiology of aging · 2012Article
- Article
- Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss.Translational research : the journal of laboratory and clinical medicine · 2011Article
- Age-related synaptic loss of the medial olivocochlear efferent innervation.Molecular neurodegeneration · 2010Article
- Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury.Journal of neurophysiology · 2007Article
- Electromotile hearing: acoustic tones mask psychophysical response to high-frequency electrical stimulation of intact guinea pig cochleae.The Journal of the Acoustical Society of America · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We applied the dopaminergic (DA) neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the guinea pig cochlear perilymph. Immunolabeling of lateral olivocochlear (LOC) neurons using antibodies against synaptophysin was reduced after the MPTP treatment. In contrast, labeling of the medial olivocochlear innervation remained intact. As after brainstem lesions of the lateral superior olive (LSO), the site of origin of the LOC neurons, the main effect of disrupting LOC innervation of the cochlea via MPTP was a depression of the amplitude of the compound action potential (CAP). CAP amplitude depression was similar to that produced by LSO lesions. Latency of the N1 component of the CAP, and distortion product otoacoustic emission amplitude and adaptation were unchanged by the MPTP treatment. This technique for selectively lesioning descending LOC efferents provides a new opportunity for examining LOC modulation of afferent activity and behavioral measures of perception.
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Registered trials
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