ArticleJournal of the Association for Research in Otolaryngology : JARO2005
Differential expression of genes within the cochlea as defined by a custom mouse inner ear microarray.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Congenital Hereditary Endothelial Dystrophy: A Review of the Molecular Pathogenesis, Genetic Basis, and Emerging Treatments.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Cell-specific α and β subunit expression patterns of NaScientific reports · 2025Article
- Single-cell RNA-sequencing of stria vascularis cells in the adult Slc26a4BMC medical genomics · 2023Article
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- Gene expression profiling of the inner ear.Journal of anatomy · 2016Review
- Identification of a gene set to evaluate the potential effects of loud sounds from seismic surveys on the ears of fishes: a study with Salmo salar.Journal of fish biology · 2014Article
- Article
- Mutation analysis of the SLC4A11 gene in Indian families with congenital hereditary endothelial dystrophy 2 and a review of the literature.Molecular vision · 2013Review
- The genetics of Fuchs' corneal dystrophy.Expert review of ophthalmology · 2012Article
- Probing the Xenopus laevis inner ear transcriptome for biological function.BMC genomics · 2012Article
- Proteomic analysis of the organ of corti using nanoscale liquid chromatography coupled with tandem mass spectrometry.International journal of molecular sciences · 2012Article
- Transcriptomic analysis of the developing and adult mouse cochlear sensory epithelia.PloS one · 2012Article
- Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse.The Journal of biological chemistry · 2011Article
- PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity.BMC developmental biology · 2010Article
- Slc4a11 gene disruption in mice: cellular targets of sensorineuronal abnormalities.The Journal of biological chemistry · 2009Article
- Synthesis of biotin-labeled RNA for gene expression measurements using oligonucleotide arrays.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Congenital hereditary endothelial dystrophy with progressive sensorineural deafness (Harboyan syndrome).Orphanet journal of rare diseases · 2008Review
- Ion channel gene expression in the inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2007Article
- Borate transporter SLC4A11 mutations cause both Harboyan syndrome and non-syndromic corneal endothelial dystrophy.Journal of medical genetics · 2007Article
- Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Microarray analyses have contributed greatly to the rapid understanding of functional genomics through the identification of gene networks as well as gene discovery. To facilitate functional genomics of the inner ear, we have developed a mouse inner-ear-pertinent custom microarray chip (CMA-IE1). Nonredundant cDNA clones were obtained from two cDNA library resources: the RIKEN subtracted inner ear set and the NIH organ of Corti library. At least 2000 cDNAs unique to the inner ear were present on the chip. Comparisons were performed to examine the relative expression levels of these unique cDNAs within the organ of Corti, lateral wall, and spiral ganglion. Total RNA samples were obtained from the three cochlear-dissected fractions from adult CF-1 mice. The total RNA was linearly amplified, and a dendrimer-based system was utilized to enhance the hybridization signal. Differentially expressed genes were verified by comparison to known gene expression patterns in the cochlea or by correlation with genes and gene families deduced to be present in the three tissue types. Approximately 22-25% of the genes on the array had significant levels of expression. A number of differentially expressed genes were detected in each tissue fraction. These included genes with known functional roles, hypothetical genes, and various unknown or uncharacterized genes. Four of the differentially expressed genes found in the organ of Corti are linked to deafness loci. None of these are hypothetical or unknown genes.
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