Evidence map›Paper›PMID 15735744›Full record

ArticleOncogene2005

Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids.

George A Mashour, Stephanie N Drissel, Silke Frahm, Faris Farassati, Robert L Martuza, Victor-F Mautner, Andrea Kindler-Röhrborn, Andreas Kurtz

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

George A MashourMolecular Neurosurgery Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Stephanie N Drissel
Silke Frahm
Faris Farassati
Robert L Martuza
Victor-F Mautner
Andrea Kindler-Röhrborn
Andreas Kurtz
Harvard University · USMassachusetts General Hospital · USUniversity of Bonn · DEUniversität Hamburg · DE

Funding

FUNCTION OF MIDKINE IN NEUROFIBROMATOSISR29NS037895 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KURTZ, ANDREAS C · 1998 to 2002
$416k
NINDS NIH HHS NS37895
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) is a common genetic disorder of the nervous system resulting in neurofibromas and malignant peripheral nerve sheath tumors (MPNST). In this study, we report the modulation of murine and human MPNST cell growth by the fatty acids docosahexaenoic acid (DHA) and arachidonic acid (AA). DHA demonstrated a tendency to stimulate cell growth at low doses and induce apoptosis at high doses, paralleled by the activation of ERK and caspase-3. Furthermore, high-dose DHA reversed the stimulation of MPNST cell growth by a number of growth factors suggested to have a pathogenic effect in NF1 and inhibited MPNST growth in vivo. AA was found to have a reciprocal activity in vitro, stimulating MPNST cell growth at comparable concentrations and reducing DHA activation of ERK. These findings introduce fatty acids as a possible regulator of MPNST development in NF1 patients.

Indexed as

AnimalsBase SequenceCell LineDNA PrimersFatty Acids, Omega-3Fatty Acids, Omega-6ImmunohistochemistryMiceMitogen-Activated Protein KinasesNerve Sheath NeoplasmsPhosphorylationReverse Transcriptase Polymerase Chain ReactionDNA PrimersFatty Acids, Omega-3Fatty Acids, Omega-6Mitogen-Activated Protein Kinases

Identifiers

PMID15735744
OpenAlexW2014211651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.