ArticleOncogene2005
Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- ceRNA Network and WGCNA Analyses of Differentially Expressed Genes in Cervical Cancer Tissues for Association with Survival of Patients.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Article
- E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair.International journal of molecular sciences · 2020Article
- Phytochemicals for the Prevention of Photocarcinogenesis.Photochemistry and photobiology · 2017Review
- Article
- E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells.Cell cycle (Georgetown, Tex.) · 2015Article
- The prognostic role of EZH2 expression in rectal cancer patients treated with neoadjuvant chemoradiotherapy.Radiation oncology (London, England) · 2014Article
- E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis.Cancer research · 2014Article
- The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM.The Journal of biological chemistry · 2013Article
- Article
- E2F1 and p53 transcription factors as accessory factors for nucleotide excision repair.International journal of molecular sciences · 2012Review
- Implication of posttranslational histone modifications in nucleotide excision repair.International journal of molecular sciences · 2012Review
- PAX Genes in Cancer; Friends or Foes?Frontiers in genetics · 2012Article
- A new role for E2F1 in DNA repair: all for the greater good.Cell cycle (Georgetown, Tex.) · 2011Article
- Variation in DNA damage response pathway activity: focus on intermediate phenotype instead of genetic polymorphisms.Cell cycle (Georgetown, Tex.) · 2011Article
- E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks.Cell cycle (Georgetown, Tex.) · 2011Article
- GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.Nucleic acids research · 2011Article
- The role of the E2F transcription factor family in UV-induced apoptosis.International journal of molecular sciences · 2011Review
- Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair.Molecular biology of the cell · 2010Article
- Mouse models for the p53 R72P polymorphism mimic human phenotypes.Cancer research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The E2F1 transcription factor regulates the expression of genes involved in cell proliferation, apoptosis and DNA repair. Following DNA damage, E2F1 is phosphorylated and stabilized, but the physiological role of E2F1 in the response to DNA damage is unclear. We find that mice lacking E2F1 have increased levels of epidermal apoptosis compared to wild-type mice following exposure to ultraviolet B (UVB) radiation. Moreover, transgenic overexpression of E2F1 in basal layer keratinocytes suppresses apoptosis induced by UVB. Inhibition of UVB-induced apoptosis by E2F1 is unexpected given that most studies have demonstrated a proapoptotic function for E2F1. E2F1-mediated suppression of apoptosis does not involve alterations in mitogen-activated protein kinase activation or Bcl-2 downregulation in response to UVB and is independent of p53. Instead, inhibition of UVB-induced apoptosis by E2F1 correlates with a stimulation of DNA repair. Mice lacking E2F1 are impaired for the removal of DNA photoproducts, while E2F1 transgenic mice repair UVB-induced DNA damage at an accelerated rate compared to wild-type mice. These findings suggest that E2F1 participates in the response to UVB by promoting DNA repair and suppressing apoptosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.