ArticleOncogene2005
The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
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- Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.Microvascular research · 2019Article
- Loss of Renal Peritubular Capillaries in Hypertensive Patients Is Detectable by Urinary Endothelial Microparticle Levels.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies - A review.Journal of advanced research · 2017Review
- Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury.Circulation · 2016Article
- Anti-angiogenic alternatives to VEGF blockade.Clinical & experimental metastasis · 2016Review
- Development of Endothelial-Specific Single Inducible Lentiviral Vectors for Genetic Engineering of Endothelial Progenitor Cells.Scientific reports · 2015Article
- γ-Actin plays a key role in endothelial cell motility and neovessel maintenance.Vascular cell · 2015Article
- Endothelial permeability and VE-cadherin: a wacky comradeship.Cell adhesion & migration · 2014Review
- The C-terminus region of β-arrestin1 modulates VE-cadherin expression and endothelial cell permeability.Cell communication and signaling : CCS · 2013Article
- Article
- iNOS activation regulates β-catenin association with its partners in endothelial cells.PloS one · 2012Article
- Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability.PloS one · 2011Article
- Wilms' tumour protein Wt1 stimulates transcription of the gene encoding vascular endothelial cadherin.Pflugers Archiv : European journal of physiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of normal and tumour vessels. In this report, we characterized the transcriptional activity of the human VE-cadherin promoter. Transient transfection assays revealed that sequences at positions --1135/-744 and -166/-5 base pairs are critical for promoter activity in endothelial cells. We show that specific sequences in the proximal region interact with Ets and Sp1 family members. Transgenic mice were created and the human VE-cadherin promoter was able to confer correct temporal and spatial expression on the LacZ gene in embryos. In adults, the transgene was specifically and strongly expressed in the lung, heart, ovary, spleen and kidney glomeruli, whereas expression was weak or absent in the vasculature of other organs, including the brain, thymus, liver and skeletal muscle. Neovessels in tumour grafts and Matrigel implants harboured strong stainings, indicating that promoter activity is enhanced in angiogenic situations. Furthermore, Matrigel and transfection assays showed that VE-cadherin promoter is subjected to bFGF induction. Transgene expression was also noticed in extravascular sites of the central nervous system, suggesting that silencer elements may be located elsewhere in the gene. These results are a first step towards addressing the organ- and tumour-specific regulation of the VE-cadherin gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.