Trial reportAmerican journal of respiratory and critical care medicine2005
The bronchial lavage of pediatric patients with asthma contains infectious Chlamydia.
Trial report in American journal of respiratory and critical care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Chlamydia pneumoniae and chronic asthma: Updated systematic review and meta-analysis of population attributable risk.PloS one · 2021Pooled it
- The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials.Drug design, development and therapy · 2018Pooled it
- Bronchoscopy in severe childhood asthma: Irresponsible or irreplaceable?Pediatric pulmonology · 2020Review
- Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or PulmonaryMicroorganisms · 2020Review
- Epidemiology of Infections and Development of Asthma.Immunology and allergy clinics of North America · 2019Review
- RespiratoryFrontiers in immunology · 2018Article
- Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides.Respiratory research · 2017Review
- Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.Mucosal immunology · 2014Article
- Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state.Immunologic research · 2013Review
- Evidence of infectious asthma phenotype: Chlamydia-induced allergy and pathogen-specific IgE in a neonatal mouse model.PloS one · 2013Article
- Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.PloS one · 2013Article
- Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers.The Journal of allergy and clinical immunology · 2012Article
- The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms.Respiratory research · 2012Article
- TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life.PloS one · 2012Article
- Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts.PLoS pathogens · 2011Article
- Role of infection in the development and exacerbation of asthma.Expert review of respiratory medicine · 2010Review
- Host cell cytokines induced by Chlamydia pneumoniae decrease the expression of interstitial collagens and fibronectin in fibroblasts.Infection and immunity · 2009Article
- Uptake and intra-inclusion accumulation of exogenous immunoglobulin by Chlamydia-infected cells.BMC microbiology · 2008Article
- The role of antibiotics in asthma.International journal of antimicrobial agents · 2007Review
- Detection of Chlamydia pneumoniae on cytospin preparations from bronchoalveolar lavage in COPD patients and in lung tissue from advanced emphysema.International journal of chronic obstructive pulmonary disease · 2007Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been a worldwide increase in the incidence of asthma, and the disease has greatly impacted the public health care system. Chlamydia pneumoniae has been reported as a possible contributing factor in asthma. The organism has been detected by polymerase chain reaction (PCR) in bronchial tissue, but there has been no direct evidence of viability. To determine the frequency of viable Chlamydia in children, blood and bronchoalveolar lavage were collected from 70 pediatric patients undergoing flexible fiberoptic bronchoscopy. Forty-two of these patients had asthma, whereas the remaining patients had various respiratory disorders. Fifty-four percent (38) of the bronchoalveolar lavage samples were PCR-positive for Chlamydia, and 31% (22) of the PCR-positive samples were positive when cultured on macrophages. Twenty-eight samples (40%) and 14 samples (20%) of the PCR- and culture-positive samples, respectively, were from patients with asthma. Culture of the blood samples revealed that 24 (34.3%) of 70 were positive for Chlamydia compared with 8 (11%) of 70 matched nonrespiratory control subjects (p < 0.01); 17 (24%) of the positive blood cultures from the respiratory group were from patients with asthma. Elevation of total IgE was strongly associated with lavage culture positivity for Chlamydia. We therefore conclude that viable Chlamydia pneumoniae organisms are frequently present in the lung lavage fluid from this cohort of predominantly asthmatic pediatric patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.