ArticleVeterinary immunology and immunopathology2005
IgE reactivity to vaccine components in dogs that developed immediate-type allergic reactions after vaccination.
Article in Veterinary immunology and immunopathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- Molecular Allergen Sensitization Profiling in a Large Cohort of Dogs Suspected of Allergic Diseases in the USA: Prevalence and Unsupervised IgE Clustering (2024-2025).Animals : an open access journal from MDPI · 2026Article
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- Safety evaluation of a buffer used in the lyophilization of canine platelets: type I hypersensitivity reaction in dogs caused by bovine serum albumin.Frontiers in veterinary science · 2024Article
- Review
- Retrospective review of diphenhydramine vs diphenhydramine plus glucocorticoid for the treatment of allergic reaction in cats.Journal of feline medicine and surgery · 2023Article
- Anaphylaxis after vaccination for cats in Japan.The Journal of veterinary medical science · 2022Article
- IgE reactivity to milk components in dogs with cutaneous adverse food reactions.The Journal of veterinary medical science · 2021Article
- Anaphylaxis after rabies vaccination for dogs in Japan.The Journal of veterinary medical science · 2021Article
- Antibody Response to Canine Parvovirus Vaccination in Dogs with Hypothyroidism Treated with Levothyroxine.Vaccines · 2021Article
- Colloids Yes or No? - a "Gretchen Question" Answered.Frontiers in veterinary science · 2021Review
- Adverse Reactions to Vaccination: From Anaphylaxis to Autoimmunity.The Veterinary clinics of North America. Small animal practice · 2018Review
- Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses.Stem cells international · 2016Article
- Recent advances in canine leptospirosis: focus on vaccine development.Veterinary medicine (Auckland, N.Z.) · 2015Review
- NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy.Skeletal muscle · 2014Article
- Effects of body weight on antibody titers against canine parvovirus type 2, canine distemper virus, and canine adenovirus type 1 in vaccinated domestic adult dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2012Article
- Large-scale survey of adverse reactions to canine non-rabies combined vaccines in Japan.Veterinary immunology and immunopathology · 2012Article
- Immunoblot analysis for IgE-reactive components of fetal calf serum in dogs that developed allergic reactions after non-rabies vaccination.Veterinary immunology and immunopathology · 2007Article
- Updated ACVIM consensus statement on leptospirosis in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic reactions after vaccination are considered as an important practical problem in dogs; however, their immunological mechanism has not been well understood. The present study was designed to investigate the relationship between IgE reactivity to the vaccines and immediate-type allergic reactions after vaccination in dogs. Sera from 10 dogs that developed immediate-type allergic reactions such as circulatory collapse, cyanosis, dyspnea, facial edema, and vomiting within 1h after vaccination with non-rabies monovalent or combined vaccines and sera from 50 dogs that did not develop allergic reactions after vaccination were collected. Serum IgE reactivity to the injected vaccines was measured by fluorometric ELISA using a mouse monoclonal anti-dog IgE antibody. Then, IgE reactivity to fetal calf serum (FCS) and stabilizer proteins (gelatin, casein, and peptone) included in the vaccines was measured in sera that had high levels of IgE to the vaccines. Levels of serum specific IgE to the vaccines in dogs with immediate-type allergic reactions (59-4173 fluorescence units [FU], mean +/- S.D.: 992.5 +/- 1181.9 FU) were significantly higher than those in control dogs (38-192 FU, 92.4 +/- 43.3 FU) (P < 0.001). Of the eight dogs that developed immediate-type allergic reactions and had high levels of serum specific IgE to the vaccines, seven had specific IgE directed to FCS. The IgE reactivity to the vaccines in sera from these dogs was almost completely inhibited by FCS. The other one dog had serum IgE directed to gelatin and casein included in the vaccine as stabilizers. The results obtained in this study suggest that immediate-type allergic reactions after vaccination in dogs were induced by type I hypersensitivity mediated by IgE directed to vaccine components. In addition, FCS, gelatin, and casein included in vaccines could be the causative allergens that induced immediate-type allergic reactions after vaccination in dogs.
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