ArticleCancer detection and prevention2005
Spectra of antinuclear antibodies in patients with squamous cell carcinoma of the lung and of the head and neck.
Article in Cancer detection and prevention, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Immune checkpoint-induced arthritis: a comprehensive single-cohort descriptive analysis from clinical evaluation to histology.Frontiers in medicine · 2025Article
- Article
- Anti-nuclear antibodies in patients with breast cancer.Clinical and experimental immunology · 2018Article
- The clinical significance of anti-mitotic spindle apparatus antibody (MSA) and anti-centromere antibody (ACA) detected in patients with small cell lung cancer (SCLC).American journal of clinical and experimental immunology · 2017Article
- Detection of brain-directed autoantibodies in the serum of non-small cell lung cancer patients.PloS one · 2017Article
- Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis.BMC cancer · 2015Article
- Immunoglobulin G from breast cancer patients in stage I stimulates muscarinic acetylcholine receptors in MCF7 cells and induces proliferation. Participation of nitric oxide synthase-derived nitric oxide.Journal of clinical immunology · 2010Article
- Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34.Cancer immunology, immunotherapy : CII · 2009Article
- Improved approach to identify cancer-associated autoantigens.Autoimmunity reviews · 2005Review
- Spectra of antinuclear antibodies in patients with squamous cell carcinoma of the lung and of the head and neck.Cancer detection and prevention · 2005Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Squamous cell carcinoma of the head and neck (HNSCC) and of the lung (LSCC) share some important risk factors, but differ substantially in terms of prognosis and treatment. A pulmonary nodule developing in patients with surgically cured HNSCC may pose a diagnostic dilemma. Markers able to distinguish these two common malignancies would be of major clinical importance. In this work we compared the spectrum of antinuclear antibodies (ANA) from 22 patients with SCCL to that of 40 patients with HNSCC. Patient sera were used to probe immunoblots of nuclear extracts from all four major lung cancer cell types, normal lung fibroblasts, cells cultured from a HNSCC, and keratinocytes cultured from the field cancerization. The ability to classify retrospectively LSCC from HNSCC based on serum ANA reactivities was determined by recursive partitioning analyses. We found that while both malignancies share reactivities to a small group of nuclear antigens, other reactivities are directed against proteins uniquely or preferentially expressed in either SCCL or in SCCHN cells. Our work shows that autoimmunity is a prominent feature of squamous cell carcinoma and suggests that molecular characterization of nuclear antigens recognized by ANAs may lead to the discovery of markers valuable to distinguish LSCC from HNSCC.
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