Evidence map›Paper›PMID 15733806›Full record

Trial reportJournal of pain and symptom management2005

The relationship of cancer symptom clusters to depressive affect in the initial phase of palliative radiation.

Richard Benoit Francoeur

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain and symptom management, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Review
  8. Article
  9. Article
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  13. Article
  14. Managing symptoms among patients with breast cancer during chemotherapy: results of a two-arm behavioral trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008
    Article
  15. Article
  16. Symptom clusters in cancer patients with bone metastases.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2007
    Article
  17. Cancer symptom clusters--a dynamic construct.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2007
    Article
  18. Symptom clusters: establishing the link between clinical practice and symptom management research.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006
    Article
  19. Article
  20. A flexible item to screen for depression in inner-city minorities during palliative care symptom assessment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Richard Benoit FrancoeurColumbia University School of Social Work, New York, NY 10027, USA.
Columbia University · US

Funding

Late-life depression masked by low sadnessR03MH064627 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI FRANCOEUR, RICHARD BENOIT · 2002 to 2003
$171k
LIVING WITH HOMECARE--CANCER PATIENTS AND CAREGIVERSR01CA048635 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHULZ, RICHARD · 1989 to 1991
–
NCI NIH HHS R01 CA048635NIMH NIH HHS R03 MH064627
6 · The paper itself

Abstract

Research on comorbidity across cancer symptoms, including pain, fatigue, and depression, could suggest if crossover effects from symptom-specific interventions are plausible. Secondary analyses were conducted on a survey of 268 cancer patients with recurrent disease from a northeastern U.S. city who were initiating palliative radiation for bone pain. Moderator regression analyses predicted variation in depressive affect that could be attributed to symptom clusters. Patients self-reported difficulty controlling each physical symptom over the past month on a Likert scale and depressive symptoms on a validated depression measure (Center for Epidemiologic Studies-Depression [CES-D]) over the past week on a four-category scale. An index of depressive affect was based on items of negative and positive affect from the CES-D. In predicting depressive affect, synergistic interactions of pain with fever, fatigue, and weight loss suggest separate pathways involving pain. A similar interaction with fever occurs when nausea was tested in place of pain. Further, the interaction between pain and fatigue is similar in form to the interaction between difficulty breathing and fatigue (when sleep is not a problem). Follow-up to the latter interaction reveals: 1) additional moderation by hypertension and palliative radiation to the hip/pelvis; and 2) a similar cluster not involving hypertension when appetite problems and weight loss were tested in place of fatigue. The significance and form of these interactions are remarkably consistent. Similar sickness mechanisms could be generating: 1) pain and nausea during fever; 2) pain and fatigue during weight loss; and 3) pain and breathing difficulty when fatigue is pronounced. Crossover effects from symptom-specific interventions appear promising.

Indexed as

AdultAgedAged, 80 and overBone NeoplasmsComorbidityData CollectionDepressive DisorderFemaleHumansIncidenceMaleMiddle AgedPainPalliative CareRisk AssessmentRisk Factors

Identifiers

PMID15733806
PMCPMC1945048
OpenAlexW1985032046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.