ReviewDrugs & aging2005
Poststroke aphasia : epidemiology, pathophysiology and treatment.
Review in Drugs & aging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 166 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment With Donepezil of Chronic Aphasia and Sensorimotor Deficits Associated to Cerebrovascular Accidents: a Double-Blind,Placebo-Controlled, Randomized Parallel Trial.
TeleRehab for Patients With Post-Stroke Communication Deficits Using Mobile Technology
A Randomized, Single Blind, Controlled, Longitudinal Study of the Effects of Venlafaxine Hydrochloride Capsules on the Language Function of Stroke Patients With Subcortical Aphasia Using fMRI
The Language Functional Reorganization Following Subcortical Cerebral Infarction: A Longitudinal fMRI Study
Effects of Combining Donepezil, Intensive Language Rehabilitation and Transcranial Direct Current Stimulation on Language Recovery and Brain Reorganization in Chronic Post-stroke Aphasia
Who cites it
166 citing papers in PubMed, 13 syntheses or guidelines pooled it, 440 citations in OpenAlex.
- Rehabilitation interventions for Wernicke's aphasia and related fluent aphasia: A systematic review of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Speech therapy for poststroke aphasia: a network meta-analysis of randomized controlled trials.PeerJ · 2026Pooled it
- Effectiveness and Safety of Butyphthalide Injection in Treatment of Aphasia after Cerebral Infarction: A Meta-analysis.Combinatorial chemistry & high throughput screening · 2026Pooled it
- Efficacy and safety of repetitive transcranial magnetic therapy for post-stroke aphasia: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2025Pooled it
- Cognitive impairment after a stroke in young adults: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- The effectiveness of the behavioural components of cognitive behavioural therapy for insomnia in older adults: A systematic review.Journal of sleep research · 2023Pooled it
- Application of diffusion tensor imaging in the diagnosis of post-stroke aphasia: a meta-analysis and systematic review.Frontiers in psychology · 2023Pooled it
- Identifying a brain network for musical rhythm: A functional neuroimaging meta-analysis and systematic review.Neuroscience and biobehavioral reviews · 2022Pooled it
- The effect of music therapy on language recovery in patients with aphasia after stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Metacognitive Treatment in Acquired Brain Injury and Its Applicability to Aphasia: A Systematic Review.Frontiers in rehabilitation sciences · 2022Pooled it
- Effects of virtual reality in post-stroke aphasia: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- The changed functional status of the brain was involved in patients with poststroke aphasia: Coordinate-based (activation likelihood estimation) meta-analysis.Brain and behavior · 2020Pooled it
- Piracetam for Aphasia in Post-stroke Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials.CNS drugs · 2016Pooled it
- Trial
- Cerebellar transcranial direct current stimulation improves quality of life in individuals with chronic poststroke aphasia.Scientific reports · 2025Trial
- Microstructural properties in subacute aphasia: concurrent and prospective relationships underpinning recovery.Brain structure & function · 2024Trial
- Domains of Health-Related Quality of Life Are Associated With Specific Deficits and Lesion Locations in Chronic Aphasia.Neurorehabilitation and neural repair · 2021Trial
- Efficacy of exercise rehabilitation program accompanied by experiential music for recovery of aphasia in single cerebrovascular accidents: a randomized controlled trial.Irish journal of medical science · 2021Trial
- Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia.Neurorehabilitation and neural repair · 2017Trial
- Developing complex interventions: lessons learned from a pilot study examining strategy training in acute stroke rehabilitation.Clinical rehabilitation · 2014Trial
106 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia is present in 21-38% of acute stroke patients and is associated with high short- and long-term morbidity, mortality and expenditure. Recovery from aphasia is possible even in severe cases. While speech-language therapy remains the mainstay treatment of aphasia, the effectiveness of conventional therapies has not been conclusively proved. This has motivated attempts to integrate knowledge from several domains in an effort to plan more rational therapies and to introduce other therapeutic strategies, including the use of intensive language therapy and pharmacological agents. Several placebo-controlled trials suggest that piracetam is effective in recovery from aphasia when started soon after the stroke, but its efficacy vanishes in patients with chronic aphasia. Drugs acting on catecholamine systems (bromocriptine, dexamfetamine) have shown varying degrees of efficacy in case series, open-label studies and placebo-controlled trials. Bromocriptine is useful in acute and chronic aphasias, but its beneficial action appears restricted to nonfluent aphasias with reduced initiation of spontaneous verbal messages. Dexamfetamine improves language function in subacute aphasia and the beneficial effect is maintained in the long term, but its use is restricted to highly selected samples. Pharmacological agents operating on the cholinergic system (e.g. donepezil) have shown promise. Data from single-case studies, case series and an open-label study suggest that donepezil may have beneficial effects on chronic poststroke aphasia. Preliminary evidence suggests that donepezil is well tolerated and its efficacy is maintained in the long term. Randomised controlled trials of donepezil and other cholinergic agents in poststroke aphasia are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.