ArticleVirchows Archiv : an international journal of pathology2005
A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by microarray-based comparative genomic hybridisation.
Article in Virchows Archiv : an international journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- A rare tonsillar metastasis of Merkel cell carcinoma: A case report.Clinical case reports · 2023Article
- A case report of 2 patients developing multiple Merkel cell carcinomas-using comparative genomic hybridization to elucidate tumor relationship.JAAD case reports · 2022Article
- Merkel Cell Carcinoma of the Maxillary Sinus: An Unusual Presentation of a Common Tumor.Head and neck pathology · 2021Article
- Article
- Two separate nodules of Merkel cell carcinoma occurring concomitantly on one cheek.Archives of craniofacial surgery · 2019Article
- A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls.JAAD case reports · 2018Article
- Merkel Cell Carcinoma of the Buccal Mucosa and Lower Lip.Head and neck pathology · 2018Article
- Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis.Dermatology practical & conceptual · 2018Article
- Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases.JAMA dermatology · 2017Article
- Multiple Merkel cell carcinomas: Late metastasis or multiple primary tumors? A molecular study.JAAD case reports · 2017Article
- Small cell neuroendocrine carcinoma of the oropharynx harbouring oncogenic HPV-infection.Head and neck pathology · 2014Article
- Amplification of thymosin beta 10 and AKAP13 genes in metastatic and aggressive papillary thyroid carcinomas.Pathology oncology research : POR · 2012Article
- Metachronous merkel cell carcinoma: a case report.Case reports in dermatology · 2011Article
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6 authors at 1 institution in 1 country.
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Abstract
Merkel cell carcinoma was diagnosed in a 79-year-old Caucasian woman. The tumour was localised to the upper lip and was in stage T2. After successful cryosurgery and a 7-year tumour-free period, a new tumour developed in her palatine tonsil. Histologically and immunohistochemically, this resembled the tumour in the lip. The regional lymph nodes were devoid of metastasis. The paraffin-embedded material of the two tumours and the unaffected lymphatic tissue were analysed with DNA microarrays for comparative genomic hybridisation to assess the genetic relationship of the tumours. In both tumours, regions on 2p and 10p were commonly over-represented, while 41 regions on chromosomes 1-4, 6, 8-9, 11 and 14-22 were commonly under-represented. Chromosomes 1, 3, 4, 16-18 and X were most frequently involved in the DNA losses. In gene copy numbers in the two tumours, 31 chromosome locations were found to be differently affected. The partly similar and partly different molecular patterns indicated a genetic relationship between the tumours and excluded the possibility that the tonsillar tumour was a metastasis. The findings suggest that a genetically altered field was the reason for the development of the tonsillar cancer; thus, it can be regarded pathogenetically as a second field tumour.
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