ArticleProceedings of the National Academy of Sciences of the United States of America2005
The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 44 citations in OpenAlex.
- Neural plate pre-patterning enables specification of intermediate neural progenitors in the spinal cord.bioRxiv : the preprint server for biology · 2025Article
- Developmental and neurobehavioral toxicity of benzotriazole ultraviolet stabilizer UV-360 on zebrafish larvae.PloS one · 2025Article
- Article
- Specification and formation of the neural crest: Perspectives on lineage segregation.Genesis (New York, N.Y. : 2000) · 2019Review
- An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system.Neural development · 2015Review
- Current perspectives of the signaling pathways directing neural crest induction.Cellular and molecular life sciences : CMLS · 2012Review
- olig2-Expressing hindbrain cells are required for migrating facial motor neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border.Developmental biology · 2011Article
- TF-Cluster: a pipeline for identifying functionally coordinated transcription factors via network decomposition of the shared coexpression connectivity matrix (SCCM).BMC systems biology · 2011Article
- Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.Human molecular genetics · 2009Article
- Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- The evolution of Olig genes and their roles in myelination.Neuron glia biology · 2008Review
- Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Rheumatoid arthritis association at 6q23.Nature genetics · 2007Article
- The olig family: phylogenetic analysis and early gene expression in Xenopus tropicalis.Development genes and evolution · 2007Article
- Dorsoventral patterning in hemichordates: insights into early chordate evolution.PLoS biology · 2006Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
olig genes encode a previously unrecognized group of vertebrate-specific basic helix-loop-helix transcription factors. As shown in mice, chickens, and zebrafish, two members of this group, olig1 and olig2, are involved in the differentiation of motoneurons and oligodendrocytes, but nothing is known about the role of the third member, olig3. Here, we show that olig3 plays an essential role in the establishment of the neural crest-lateral neural plate boundary. In zebrafish embryos, morpholino-induced olig3 inactivation dramatically increases the number of neural crest cells, but lateral neural plate fates (interneurons and astrocytes) are missing. Zebrafish swirl mutants that have impaired bone morphogenetic protein signaling and lack neural crest cells display an expanded olig3 expression domain. Moreover, olig3 is up-regulated in mindbomb mutants lacking the neural crest because of an impaired notch signaling, and olig3 repression in such mutants rescues the neural crest. In addition, olig3 regulates ngn1 and deltaA expression in interneuron precursors. Our results indicate that olig3 has an essential proneural activity in the dorsal spinal cord and cooperates with the Delta/Notch regulatory loop to establish the boundary between the neural crest and the lateral neural plate. Thus, a proper regulation of the olig gene family is essential for the formation of three cell types (oligodendrocytes, astrocytes, and neural crest) that are unique to vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.