ArticleJournal of virology2005
Size heterogeneity in the 3' noncoding region of South American isolates of yellow fever virus.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- A safer cell-based yellow fever live attenuated vaccine protects mice against YFV infection.iScience · 2024Article
- 5'/3' RACE method for sequencing the 5' and 3' untranslated regions of Zika virus.Archives of virology · 2023Article
- Molecular Characterization and Phylogenetic Analysis of the 2019 Dengue Outbreak in Wenzhou, China.Frontiers in cellular and infection microbiology · 2022Article
- Review
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- Complete Genome Characterization of the 2017 Dengue Outbreak in Xishuangbanna, a Border City of China, Burma and Laos.Frontiers in cellular and infection microbiology · 2018Article
- Genetic characterization, molecular epidemiology, and phylogenetic relationships of insect-specific viruses in the taxon Negevirus.Virology · 2017Article
- Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes.Frontiers in microbiology · 2017Review
- Isolation of Madre de Dios Virus (Orthobunyavirus; Bunyaviridae), an Oropouche Virus Species Reassortant, from a Monkey in Venezuela.The American journal of tropical medicine and hygiene · 2016Article
- A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections.Virology journal · 2016Review
- RNA Structure Duplications and Flavivirus Host Adaptation.Trends in microbiology · 2016Review
- Biological and phylogenetic characteristics of yellow fever virus lineages from West Africa.Journal of virology · 2013Article
- Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forces.PLoS pathogens · 2013Article
- Genomic and phylogenetic characterization of Brazilian yellow fever virus strains.Journal of virology · 2012Article
- Identification and characterization of the short variable region of the Japanese encephalitis virus 3' NTR.Virus genes · 2012Article
- Evaluation of two molecular methods for the detection of Yellow fever virus genome.Journal of virological methods · 2011Article
- Molecular epidemiology of yellow fever in Bolivia from 1999 to 2008.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2011Article
- An RNA pseudoknot is required for production of yellow fever virus subgenomic RNA by the host nuclease XRN1.Journal of virology · 2010Article
- Yellow fever virus maintenance in Trinidad and its dispersal throughout the Americas.Journal of virology · 2010Article
- Identification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicity.Virology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The 3' noncoding region (3' NCR) of flaviviruses contains secondary and tertiary structures essential for virus replication. Previous studies of yellow fever virus (YFV) and dengue virus have found that modifications to the 3' NCR are sometimes associated with attenuation in vertebrate and/or mosquito hosts. The 3' NCRs of 117 isolates of South American YFV have been examined, and major deletions and/or duplications of conserved RNA structures have been identified in several wild-type isolates. Nineteen isolates (designated YF-XL isolates) from Brazil, Trinidad, and Venezuela, dating from 1973 to 2001, exhibited a 216-nucleotide (nt) duplication, yielding a tandem repeat of conserved hairpin, stem-loop, dumbbell, and pseudoknot structures. YF-XL isolates were found exclusively within one subclade of South American genotype I YFV. One Brazilian isolate exhibited, in addition to the 216-nt duplication, a deletion of a 40-nt repeated hairpin (RYF) motif (YF-XL-DeltaRYF). To investigate the biological significance of these 3' NCR rearrangements, YF-XL-DeltaRYF and YF-XL isolates, as well as other South American YFV isolates, were evaluated for three phenotypes: growth kinetics in cell culture, neuroinvasiveness in suckling mice, and ability to replicate and produce disseminated infections in Aedes aegypti mosquitoes. YF-XL-DeltaRYF and YF-XL isolates showed growth kinetics and neuroinvasive characteristics comparable to those of typical South American YFV isolates, and mosquito infectivity trials demonstrated that both types of 3' NCR variants were capable of replication and dissemination in a laboratory-adapted colony of A. aegypti.
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