ArticleInfection and immunity2005
GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage.Toxins · 2025Article
- Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.BMC immunology · 2012Article
- Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control.BMC systems biology · 2012Article
- Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy.PloS one · 2012Article
- The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells.PloS one · 2010Article
- Cellular and systemic effects of anthrax lethal toxin and edema toxin.Molecular aspects of medicine · 2009Review
- Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent.PloS one · 2009Article
- The case for developing consensus standards for research in microbial pathogenesis: Bacillus anthracis toxins as an example.Infection and immunity · 2009Article
- Non-canonical effects of anthrax toxins on haematopoiesis: implications for vaccine development.Journal of cellular and molecular medicine · 2009Article
- Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells.FEMS immunology and medical microbiology · 2009Article
- Bacillus anthracis lethal toxin represses MMTV promoter activity through transcription factors.Journal of molecular biology · 2009Article
- Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.Critical care medicine · 2009Article
- Efficacy of a vaccine based on protective antigen and killed spores against experimental inhalational anthrax.Infection and immunity · 2009Article
- Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model.Infection and immunity · 2009Article
- Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames spores.Microbial pathogenesis · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.