ArticleInfection and immunity2005
Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- An In Vitro A-431 Epithelial Cell Infection Model for Studying Fungal Pathogenicity and Immune Responses Associated With Vulvovaginal Candidiasis.Bio-protocol · 2026Article
- Vaginal Transcriptional Signatures of the Neutrophil-Driven Immune Response Correlate With Clinical Severity During Recurrent Vulvovaginal Candidiasis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- Article
- Genetic modification ofMicrobiology (Reading, England) · 2024Article
- Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology.Oxford open immunology · 2024Review
- Growing importance of urogenital candidiasis in individuals with diabetes: A narrative review.World journal of diabetes · 2022Review
- Amino Acid Sensing and Assimilation by the Fungal PathogenPathogens (Basel, Switzerland) · 2021Review
- In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis.Iranian biomedical journal · 2020Article
- Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1-3 Genes Expression in Fluconazole-ResistantInfection and drug resistance · 2020Article
- Cariogenicity of Candida albicans of distinct genotypes among 3-5-year-old Uygur children in Kashgar, China- a case-control study.BMC oral health · 2018Article
- Novel Mechanism behind the Immunopathogenesis of Vulvovaginal Candidiasis: "Neutrophil Anergy".Infection and immunity · 2018Review
- Overexpression of Candida albicans Secreted Aspartyl Proteinase 2 or 5 Is Not Sufficient for Exacerbation of Immunopathology in a Murine Model of Vaginitis.Infection and immunity · 2017Article
- The vaginal mycobiome: A contemporary perspective on fungi in women's health and diseases.Virulence · 2017Review
- A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation.BJOG : an international journal of obstetrics and gynaecology · 2017Review
- Inhibitory effects of carvacrol on the expression of secreted aspartyl proteinases 1-3 in fluconazole-resistantIranian journal of microbiology · 2016Article
- Identification of novel mechanisms involved in generating localized vulvodynia pain.American journal of obstetrics and gynecology · 2015Article
- Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome.mBio · 2015Article
- Candida vaginitis: when opportunism knocks, the host responds.PLoS pathogens · 2014Review
- Fungal morphogenetic pathways are required for the hallmark inflammatory response during Candida albicans vaginitis.Infection and immunity · 2014Article
- The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity.Infection and immunity · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaginal infections caused by the opportunistic yeast Candida albicans are a significant problem in women of child-bearing age. Several factors are recognized as playing a crucial role in the pathogenesis of superficial candidiasis; these factors include hyphal formation, phenotypic switching, and the expression of virulence factors, including a 10-member family of secreted aspartic proteinases. In the present investigation, we analyzed the secreted aspartic proteinase gene (SAP) expression profile of C. albicans that is elicited in the course of vaginal infection in mice and how this in vivo expression profile is associated with hyphal formation. We utilized two different genetic reporter systems that allowed us to observe SAP expression on a single-cell basis, a recombination-based in vivo expression technology and green fluorescent protein-expressing Candida reporter strains. Of the six SAP genes that were analyzed (SAP1 to SAP6), only SAP4 and SAP5 were detectably induced during infection in this model. Expression of both of these genes was associated with hyphal growth, although not all hyphal cells detectably expressed SAP4 and SAP5. SAP5 expression was induced soon after infection, whereas SAP4 was expressed at later times and in fewer cells compared with SAP5. These findings point to a link between morphogenetic development and expression of virulence genes during Candida vaginitis in mice, where host signals induce both hyphal formation and expression of SAP4 and SAP5, but temporal gene expression patterns are ultimately controlled by other factors.
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