ArticleInfection and immunity2005
Use of genome-wide expression profiling and mutagenesis to study the intestinal lifestyle of Campylobacter jejuni.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 128 citations in OpenAlex.
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- Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation.Metallomics : integrated biometal science · 2021Review
- RevisitingFrontiers in cellular and infection microbiology · 2020Review
- The Anti-Microorganisms · 2019Article
- Survival Mechanisms ofFrontiers in microbiology · 2019Article
- Review
- RNAseq Reveals Complex Response ofFrontiers in microbiology · 2017Article
- Phenotypic and Transcriptomic Responses ofFrontiers in microbiology · 2017Article
- Insights into Campylobacter jejuni colonization and enteritis using a novel infant rabbit model.Scientific reports · 2016Article
- Cloning, Expression, Purification, Regulation, and Subcellular Localization of a Mini-protein from Campylobacter jejuni.Current microbiology · 2016Article
- The Campylobacter jejuni Ferric Uptake Regulator Promotes Acid Survival and Cross-Protection against Oxidative Stress.Infection and immunity · 2016Article
- Measuring Escherichia coli Gene Expression during Human Urinary Tract Infections.Pathogens (Basel, Switzerland) · 2016Article
- Campylobacter jejuni CsrA Regulates Metabolic and Virulence Associated Proteins and Is Necessary for Mouse Colonization.PloS one · 2016Article
- A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni.Frontiers in microbiology · 2015Article
- Article
- Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni.Frontiers in cellular and infection microbiology · 2014Review
- Adaptive strategies and pathogenesis of Clostridium difficile from in vivo transcriptomics.Infection and immunity · 2013Article
- Comparative genomics of Campylobacter concisus isolates reveals genetic diversity and provides insights into disease association.BMC genomics · 2013Article
- Enhanced, sialoadhesin-dependent uptake of Guillain-Barre syndrome-associated Campylobacter jejuni strains by human macrophages.Infection and immunity · 2013Article
- The complete Campylobacter jejuni transcriptome during colonization of a natural host determined by RNAseq.PloS one · 2013Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Campylobacter jejuni is the most common bacterial cause of diarrhea worldwide. To colonize the gut and cause infection, C. jejuni must successfully compete with endogenous microbes for nutrients, resist host defenses, persist in the intestine, and ultimately infect the host. These challenges require the expression of a battery of colonization and virulence determinants. In this study, the intestinal lifestyle of C. jejuni was studied using whole-genome microarray, mutagenesis, and a rabbit ileal loop model. Genes associated with a wide range of metabolic, morphological, and pathological processes were expressed in vivo. The in vivo transcriptome of C. jejuni reflected its oxygen-limited, nutrient-poor, and hyperosmotic environment. Strikingly, the expression of several C. jejuni genes was found to be highly variable between individual rabbits. In particular, differential gene expression suggested that C. jejuni extensively remodels its envelope in vivo by differentially expressing its membrane proteins and by modifying its peptidoglycan and glycosylation composition. Furthermore, mutational analysis of seven genes, hspR, hrcA, spoT, Cj0571, Cj0178, Cj0341, and fliD, revealed an important role for the stringent and heat shock response in gut colonization. Overall, this study provides new insights on the mechanisms of gut colonization, as well as possible strategies employed by Campylobacter to resist or evade the host immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.