ArticleInfection and immunity2005
Phenotypic switching of Cryptococcus neoformans can produce variants that elicit increased intracranial pressure in a rat model of cryptococcal meningoencephalitis.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Article
- Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection.PLoS neglected tropical diseases · 2023Article
- Sustained intrathecal delivery of amphotericin B using an injectable and biodegradable thermogel.Drug delivery · 2021Article
- Article
- Cryptococcal Disease in HIV-Infected Children.Current infectious disease reports · 2016Review
- Aging as an emergent factor that contributes to phenotypic variation in Cryptococcus neoformans.Fungal genetics and biology : FG & B · 2015Review
- Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.The Journal of infectious diseases · 2014Article
- Article
- Allergen1 regulates polysaccharide structure in Cryptococcus neoformans.Molecular microbiology · 2013Article
- EDTA inhibits biofilm formation, extracellular vesicular secretion, and shedding of the capsular polysaccharide glucuronoxylomannan by Cryptococcus neoformans.Applied and environmental microbiology · 2012Article
- Variability of phenotypic traits in Cryptococcus varieties and species and the resulting implications for pathogenesis.Future microbiology · 2010Review
- Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure.AIDS (London, England) · 2010Article
- Antigenic and phenotypic variations in fungi.Cellular microbiology · 2009Review
- Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans.Infection and immunity · 2009Article
- Phenotypic switching of Cryptococcus neoformans and Cryptococcus gattii.Mycopathologia · 2008Review
- Phenotypic Switching in Fungi.Current fungal infection reports · 2008Article
- Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans.Eukaryotic cell · 2007Article
- Phenotypic switching and its implications for the pathogenesis of Cryptococcus neoformans.FEMS yeast research · 2006Review
- Phenotypic switching in Cryptococcus neoformans.Microbiology (Reading, England) · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Increased intracranial pressure (ICP) plays an important role in the morbidity and mortality of cryptococcal meningoencephalitis. The microbial and host factors that contribute to the development of increased ICP are poorly understood. We found that phenotypic switch variants of Cryptococcus neoformans (smooth and mucoid) differed in their abilities to promote increased ICP in a rat model of cryptococcal meningitis. Rats infected with the mucoid variant developed increased ICP, whereas rats infected with the smooth parent did not. This trend correlated with a shorter survival time and a higher cerebrospinal fluid (CSF) fungal burden for mucoid variant-infected rats, although brain fungal burdens were comparable between mucoid variant- and smooth parent-infected rats. Magnetic resonance imaging revealed enhanced T2 signal intensity over the surfaces of the brains of mucoid variant-infected rats. In addition, more polysaccharide accumulated in the CSF and brains of mucoid variant-infected rats. The accumulation of glucorunoxylomannan was associated with elevated levels of MCP-1 (CCL2) and, accordingly, a more pronounced but ineffective monocytic inflammatory response in the meninges of mucoid variant-infected rats. In summary, these findings suggest that strain-specific characteristics can influence the development of increased ICP and indicate a manner in which phenotypic switching could influence the outcome of a central nervous system infection.
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Registered trials
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