ArticleInfection and immunity2005
Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Chlamydia pneumoniae Seropositivity is Associated with Cardiovascular Events in the General Population: The Nagahama Study.Journal of atherosclerosis and thrombosis · 2026Article
- Nasal microbiome in relation to olfactory dysfunction and cognitive decline in older adults.Translational psychiatry · 2025Article
- Infections withFrontiers in aging neuroscience · 2025Review
- Review
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- The Adult Neurogenesis Theory of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Infectious origin of Alzheimer's disease: Amyloid beta as a component of brain antimicrobial immunity.PLoS pathogens · 2022Review
- Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer's disease risk.Scientific reports · 2022Article
- Inflammation Spreading: Negative Spiral Linking Systemic Inflammatory Disorders and Alzheimer's Disease.Frontiers in cellular neuroscience · 2021Article
- Article
- Review
- Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco.Frontiers in genetics · 2018Review
- Microbes and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2016Review
- Chlamydia pneumoniae Clinical Isolate from Gingival Crevicular Fluid: A Potential Atherogenic Strain.Frontiers in cellular and infection microbiology · 2015Article
- Sepsis in old age: review of human and animal studies.Aging and disease · 2014Review
- Detection of bacterial antigens and Alzheimer's disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae.Frontiers in aging neuroscience · 2014Article
- Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: a brief overview.International journal of molecular sciences · 2013Review
- Effect of age and vaccination on extent and spread of Chlamydia pneumoniae infection in C57BL/6 mice.Immunity & ageing : I & A · 2012Article
- Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember?Medical microbiology and immunology · 2010Review
- Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.BMC neuroscience · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The intracellular bacterium Chlamydophila ("Chlamydia") pneumoniae is a pathogen for several respiratory diseases and may be a factor in the pathogenesis of chronic diseases of aging including atherosclerosis and Alzheimer's disease. We assessed whether aging is coupled with increased burden of infection in BALB/c mice after intranasal infection by C. pneumoniae. Six- and twenty-month-old BALB/c mice were infected intranasally with 5 x 10(4) inclusion forming units (IFU) or 5 x 10(5) IFU of C. pneumoniae. Lung, brain, and heart tissue were analyzed for infectious C. pneumoniae and for Chlamydophila antigen by immunohistochemistry. At both doses, aging was associated with a decreased proportion of animals that cleared infection from the lung and greater burden of infectious organism within the lung. We observed dose-dependent spread to the heart/ascending aorta in animals infected with C. pneumoniae. In mice given 5 x 10(4) IFU, spread to the heart by day 14 was only observed in old mice. By day 28, all animals inoculated with 5 x 10(4) IFU showed evidence of spread to the heart, although higher C. pneumoniae titers were observed in the hearts from old mice. In mice inoculated with 5 x 10(5) IFU, spread of C. pneumoniae to the heart was evident by day 14, with no discernible age effect. C. pneumoniae was also recovered from the central nervous system (brain and olfactory bulb) of all mice by day 28 postinfection, with higher C. pneumoniae titers in old animals than in young animals. Our results suggest that infection with C. pneumoniae may be more severe in old animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.