ArticleInfection and immunity2005
Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Gut microbiota and tuberculosis.iMeta · 2025Review
- Gut microbiome, T cell subsets, and cytokine analysis identify differential biomarkers in tuberculosis.Frontiers in immunology · 2024Article
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- Methylation changes induced by a glycodendropeptide immunotherapy and associated to tolerance in mice.Frontiers in immunology · 2022Article
- Adenosine receptor ligation tips the uveitogenic Th1 and Th17 balance towards the latter in experimental autoimmune uveitis-induced mouse.Current research in immunology · 2021Article
- Transcriptional profiling of human macrophages during infection withRNA biology · 2020Article
- CD73Frontiers in immunology · 2020Article
- Pertussis vaccines and protective immunity.Current opinion in immunology · 2019Review
- IL-23 drives differentiation of peripheral γδ17 T cells from adult bone marrow-derived precursors.EMBO reports · 2017Article
- Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/- mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-γ production.European journal of immunology · 2010Article
- Article
- Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice.PloS one · 2009Article
- A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Concurrent exposure to microbial products and food antigens triggers initiation of food allergy.North American journal of medical sciences · 2009Article
- The role of Toll-like receptor-4 in pertussis vaccine-induced immunity.BMC immunology · 2008Article
- Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses.Microbes and infection · 2008Article
- Th17 cells: a new fate for differentiating helper T cells.Immunologic research · 2008Review
- IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.The Journal of biological chemistry · 2007Article
- Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretion.Infection and immunity · 2007Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bordetella pertussis, the causative agent of whooping cough, is internalized by several cell types, including epithelial cells, monocytes, and neutrophils. Although its ability to survive intracellularly is still debated, it has been proven that cell-mediated immunity (CMI) plays a pivotal role in protection. In this study we aimed to clarify the interaction of B. pertussis with human monocyte-derived dendritic cells (MDDC), evaluating the ability of the bacterium to enter MDDC, to survive intracellularly, to interfere with the maturation process and functional activities, and to influence the host immune responses. The results obtained showed that B. pertussis had a low capability to be internalized by-and to survive in-MDDC. Upon contact with the bacteria, immature MDDC were induced to undergo phenotypic maturation and acquired antigen-presenting-cell functions. Despite the high levels of interleukin-10 (IL-10) and the barely detectable levels of IL-12 induced by B. pertussis, the bacterium induced maturation of MDDC and T helper 1 (Th1) polarized effector cells. Gene expression analysis of the IL-12 cytokine family clearly demonstrated that B. pertussis induced high levels of the p40 and p19 subunits of IL-23 yet failed to induce the expression of the p35 subunit of IL-12. Overall our findings show that B. pertussis, even if it survives only briefly in MDDC, promotes the synthesis of IL-23, a newly discovered Th1 polarizing cytokine. A Th1-oriented immune response is thus allowed, relevant in the induction of an adequate CMI response, and typical of protection induced by natural infection or vaccination with whole-cell vaccines.
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