ArticleJournal of anatomy2005
Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences.
Article in Journal of anatomy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Pathophysiology of Femoral Fractures in Hypophosphatasia.Current osteoporosis reports · 2025Review
- Preclinical Rodent Models for Human Bone Disease, Including a Focus on Cortical Bone.Endocrine reviews · 2024Review
- Vitronectin regulates osteoclastogenesis and bone remodeling in a mouse model of osteoporosis.Anatomy & cell biology · 2024Article
- Tensile Yield Strain of Human Cortical Bone from the Femoral Diaphysis Is Constant among Healthy Adults and across the Anatomical Quadrants.Bioengineering (Basel, Switzerland) · 2024Article
- Article
- Region-specific associations among tissue-level mechanical properties, porosity, and composition in human male femora.Journal of biomechanics · 2022Article
- Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes.Cellular and molecular life sciences : CMLS · 2021Review
- An examination of histomorphometric relationships in the anterior and posterior human femoral cortex.Journal of bone and mineral metabolism · 2021Article
- Bone remodeling in the longest living rodent, the naked mole-rat: Interelement variation and the effects of reproduction.Journal of anatomy · 2021Article
- Bone loss markers in the earliest Pacific Islanders.Scientific reports · 2021Article
- External bone size identifies different strength-decline trajectories for the male human femora.Journal of structural biology · 2020Article
- Finite Element Analysis of Orthopedic Hip Implant with Functionally Graded Bioinspired Lattice Structures.Biomimetics (Basel, Switzerland) · 2020Article
- A study of intracortical porosity's area fractions and aspect ratios using computer vision and pulse-coupled neural networks.Medical & biological engineering & computing · 2019Article
- Homogenization of cortical bone reveals that the organization and shape of pores marginally affect elasticity.Journal of the Royal Society, Interface · 2019Article
- Collagen proton fraction from ultrashort echo time magnetization transfer (UTE-MT) MRI modelling correlates significantly with cortical bone porosity measured with micro-computed tomography (μCT).NMR in biomedicine · 2019Article
- Article
- Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.Bone reports · 2017Article
- Are DXA/aBMD and QCT/FEA Stiffness and Strength Estimates Sensitive to Sex and Age?Annals of biomedical engineering · 2017Article
- Histomorphometric and osteocytic characteristics of cortical bone in male subtrochanteric femoral shaft.Journal of anatomy · 2017Article
- Intraskeletal variation in human cortical osteocyte lacunar density: Implications for bone quality assessment.Bone reports · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated age and sex differences in patterns of porosity distribution in the midshaft of the human femur. Cross-sections were obtained from 168 individuals from a modern Australian population. The sample comprised 73 females and 95 males, aged between 20 and 97 years. Microradiographs were made of 100-microm sections and pore and bone areas were determined using image processing software. Initially the sample was divided by age: young (20-44 years), middle (45-64 years) and old (65+ years), but it was found that analysis on the basis of the ratio of medullary area to total subperiosteal area gave clearer results. The cortex was divided into three rings radially and into octants circumferentially and the porosity of each segment was calculated. Results showed that a pattern with raised porosity in the posterior and anterolateral regions, and with greater porosity in the inner parts of the cortex, becomes more pronounced with age. In males this pattern develops steadily; in females there are much greater differences between the middle and older groups than earlier in life. The patterns observed are consistent with progressive bone loss occurring along a neutral axis of the cortex where bending stress is lowest and the mechanical advantage of the bone is least.
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