ArticleJournal of clinical microbiology1992
Use of a mouse model to evaluate clinical and environmental isolates of Sporothrix spp. from the largest U.S. epidemic of sporotrichosis.
Article in Journal of clinical microbiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Sporothrix is neglected among the neglected.PLoS pathogens · 2025Article
- Current Models to Study theFrontiers in fungal biology · 2022Review
- Article
- Efficacy of posaconazole in murine experimental sporotrichosis.Antimicrobial agents and chemotherapy · 2012Article
- Sporothrix schenckii and Sporotrichosis.Clinical microbiology reviews · 2011Review
- Sporotrichosis caused by Sporothrix globosa in Rio De Janeiro, brazil: case report.Mycopathologia · 2010Article
- Differences in virulence between isolates of feline Sporotrichosis.Mycopathologia · 2005Article
- Detection of Sporothrix schenckii in clinical samples by a nested PCR assay.Journal of clinical microbiology · 2003Article
- Evidence for growth of Sporothrix schenckii on dead but not on living sphagnum moss.Mycopathologia · 1993Article
- DNA typing of isolates associated with the 1988 sporotrichosis epidemic.Journal of clinical microbiology · 1992Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five clinical and 69 environmental isolates from the largest U.S. epidemic of sporotrichosis were evaluated in NYLAR male mice following intravenous injection of 5 x 10(6) to 2 x 10(8) conidia per mouse. The clinical isolates and eight environmental isolates produced 100% mortality in groups of three mice each between 12 and 24 days after injection. These virulent isolates grew at 37 degrees C, were dematiaceous by virtue of melanin (melanized) on permissive media (e.g., potato dextrose agar), produced ovoid conidia borne sympodially on lateral conidiophores and pleurogenously about the main hyphal axis, and were identified as Sporothrix schenckii. Two melanized environmental isolates that grew at 35 degrees C but not at 37 degrees C were not virulent and had subtle morphological differences from S. schenckii. The remaining environmental isolates were not melanized, were not virulent, and were not S. schenckii; five were identified as Ophiostoma stenoceras and the remainder were identified as Sporothrix spp. Quantitative organ cultures revealed that clinical isolates grew exponentially in livers and testes, in contrast to an isolate of O. stenoceras that was eliminated from liver, lung, and spleen but that persisted in the testes throughout the 14-day sample period. This model helped to confirm the identification of S. schenckii isolates obtained from the environment.
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