Evidence map›Paper›PMID 15728937›Full record

ArticleAntimicrobial agents and chemotherapy2005

Combined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus.

Manuel Cuenca-Estrella, Alicia Gomez-Lopez, Guillermo Garcia-Effron, Laura Alcazar-Fuoli, Emilia Mellado, Maria J Buitrago, Juan L Rodriguez-Tudela

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Frontiers in cellular and infection microbiology · 2022
    Article
  5. Article
  6. Article
  7. Antimicrobial agents and chemotherapy · 2018
    Article
  8. Article
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  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manuel Cuenca-EstrellaServicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2. 28220 Majadahonda (Madrid), Spain. mcuenca-estrella@isciii.es
Alicia Gomez-Lopez
Guillermo Garcia-Effron
Laura Alcazar-Fuoli
Emilia Mellado
Maria J Buitrago
Juan L Rodriguez-Tudela

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interactions in vitro between amphotericin B, itraconazole, voriconazole, and caspofungin against itraconazole-resistant Aspergillus fumigatus clinical strains were determined. Differential results were obtained depending on the criteria (MIC or minimal effective concentration) used. Caspofungin and voriconazole exhibited the most potent interactions, with synergy against at least 50% of isolates, and the average fractional concentration index was 0.38. Antagonism was not found for any combination.

Indexed as

Amphotericin BAntifungal AgentsAspergillus fumigatusCaspofunginDrug Resistance, FungalEchinocandinsHumansItraconazoleLipopeptidesMicrobial Sensitivity TestsPeptides, CyclicPyrimidinesTriazolesVoriconazoleAmphotericin BAntifungal AgentsCaspofunginEchinocandinsItraconazoleLipopeptidesPeptides, CyclicPyrimidinesTriazolesVoriconazole

Identifiers

PMID15728937
PMCPMC549263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.