ArticleAntimicrobial agents and chemotherapy2005
A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Control ofMicrobiology spectrum · 2023Article
- Gut-targeted nanoparticles deliver specifically targeted antimicrobial peptides againstScience advances · 2023Article
- [Materials for Selective Inhibition ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Compatibility, Cytotoxicity, and Gastrointestinal Tenacity of Bacteriocin-Producing Bacteria Selected for a Consortium Probiotic Formulation to Be Used in Livestock Feed.Probiotics and antimicrobial proteins · 2021Article
- Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms.Molecular oral microbiology · 2019Review
- Self-assembled DNA-THPS hydrogel as a topical antibacterial agent for wound healing.ACS applied bio materials · 2019Article
- Selective activities of STAMPs againstExperimental and therapeutic medicine · 2018Article
- The therapeutic potential of bacteriocins as protein antibiotics.Emerging topics in life sciences · 2017Article
- Pro-moieties of antimicrobial peptide prodrugs.Molecules (Basel, Switzerland) · 2015Review
- Aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug.Biofouling · 2013Article
- Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?International journal of antimicrobial agents · 2011Review
- Communication: Antimicrobial Activity of SMAP28 with a Targeting Domain for Porphyromonas gingivalis.Probiotics and antimicrobial proteins · 2010Article
- Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture.International journal of antimicrobial agents · 2009Article
- Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide.Antimicrobial agents and chemotherapy · 2006Article
- Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp.Antimicrobial agents and chemotherapy · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.