ArticleAntimicrobial agents and chemotherapy2005
Synthesis and antileishmanial activities of novel 3-substituted quinolines.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- SystematicFrontiers in chemistry · 2021Article
- Antileishmanial activity of synthetic analogs of the naturally occurring quinolone alkaloid N-methyl-8-methoxyflindersin.PloS one · 2020Article
- Vinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts.Synthesis · 2018Article
- Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole.Molecular and cellular biochemistry · 2014Article
- Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB/c mice.Memorias do Instituto Oswaldo Cruz · 2013Article
- Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.PLoS neglected tropical diseases · 2012Article
- Discovery of safe and orally effective 4-aminoquinaldine analogues as apoptotic inducers with activity against experimental visceral leishmaniasis.Antimicrobial agents and chemotherapy · 2012Article
- Mitochondria and trypanosomatids: targets and drugs.Pharmaceutical research · 2011Review
- Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.Antimicrobial agents and chemotherapy · 2010Article
- Leishmaniasis treatment--a challenge that remains: a review.Parasitology research · 2008Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antileishmanial efficacy of four novel quinoline derivatives was determined in vitro against Leishmania chagasi, using extracellular and intracellular parasite models. When tested against L. chagasi-infected macrophages, compound 3b demonstrated 8.3-fold greater activity than did the standard pentavalent antimony. No significant activity was found for compounds 3a, 4a, and 4b. The antilesihmanial effect of compound 3b was independent of host cell activation, as demonstrated by nitric oxide production. Ultrastructural studies of promastigotes treated with compound 3b showed mainly enlarged mitochondria, with matrix swelling and reduction in the number of cristae. Synthetic analogues based on the quinoline ring structure, already an established template for antiparasitic drugs, could provide further useful compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.