ArticleMolecular biology of the cell2005
A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- Visualization of the Cytoskeleton in Fixed Drosophila Embryos.Current protocols · 2025Article
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- STAM Prolongs Clear Cell Renal Cell Carcinoma Patients' SurvivalFrontiers in oncology · 2021Article
- Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis.PloS one · 2021Article
- The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease.Cancers · 2020Review
- Genetic and Cell Biology Methods to Study ESCRTs in Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Membrane Tethering Complexes in the Endosomal System.Frontiers in cell and developmental biology · 2016Review
- Drosophila spermiogenesis: Big things come from little packages.Spermatogenesis · 2012Article
- Shaping development with ESCRTs.Nature cell biology · 2011Review
- Review
- Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis.Development (Cambridge, England) · 2011Article
- CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines.Journal of cell science · 2010Article
- Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.Development (Cambridge, England) · 2010Article
- Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants.Journal of cell science · 2009Article
- The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles.Molecular biology of the cell · 2009Article
- Article
- ESCRT factors restrict mycobacterial growth.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes.PLoS biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Proteins that constitute the endosomal sorting complex required for transport (ESCRT) are necessary for the sorting of proteins into multivesicular bodies (MVBs) and the budding of several enveloped viruses, including HIV-1. The first of these complexes, ESCRT-I, consists of three proteins: Vps28p, Vps37p, and Vps23p or Tsg101 in mammals. Here, we characterize a mutation in the Drosophila homolog of vps28. The dVps28 gene is essential: homozygous mutants die at the transition from the first to second instar. Removal of maternally contributed dVps28 causes early embryonic lethality. In such embryos lacking dVps28, several processes that require the actin cytoskeleton are perturbed, including axial migration of nuclei, formation of transient furrows during cortical divisions in syncytial embryos, and the subsequent cellularization. Defects in actin cytoskeleton organization also become apparent during sperm individualization in dVps28 mutant testis. Because dVps28 mutant cells contained MVBs, these defects are unlikely to be a secondary consequence of disrupted MVB formation and suggest an interaction between the actin cytoskeleton and endosomal membranes in Drosophila embryos earlier than previously appreciated.
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