ArticleBritish journal of sports medicine2005
Does prolonged cycling of moderate intensity affect immune cell function?
Article in British journal of sports medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Effect of Acute and Chronic Aerobic Exercise on Immunological Markers: A Systematic Review.Frontiers in physiology · 2019Pooled it
- Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners.European journal of applied physiology · 2009Trial
- The role of different physical exercises as an anti-aging factor in different stem cells.Biogerontology · 2025Review
- Sportomics Analyses of the Exercise-Induced Impact on Amino Acid Metabolism and Acute-Phase Protein Kinetics in Female Olympic Athletes.Nutrients · 2024Article
- The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting with a High-Fat Diet.Medicina (Kaunas, Lithuania) · 2023Article
- Cardiovascular risk in fire academy instructors during live-fire simulation activity.Annals of burns and fire disasters · 2018Article
- Leukocyte Populations are Associated with Heart Rate Variability After a Triathlon.Journal of human kinetics · 2016Article
- Cardiopulmonary exercise testing in cancer patients: should we really refrain from considering it for preparticipation screening?The oncologist · 2015Article
- Exercise training and immune crosstalk in breast cancer microenvironment: exploring the paradigms of exercise-induced immune modulation and exercise-induced myokines.American journal of translational research · 2014Review
- Pathways to interleukin-6 in healthy males and serious leisure male athletes: physical activity, body composition and age.PloS one · 2012Article
- Effect of moderate aerobic cycling on some systemic inflammatory markers in healthy active collegiate men.International journal of general medicine · 2011Article
- Circulating androgens in women: exercise-induced changes.Sports medicine (Auckland, N.Z.) · 2011Review
- The effect of tapering period on plasma pro-inflammatory cytokine levels and performance in elite male cyclists.Journal of sports science & medicine · 2009Article
- Lactate threshold concepts: how valid are they?Sports medicine (Auckland, N.Z.) · 2009Review
- Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats.European journal of applied physiology · 2008Article
- Effects of rugby sevens matches on human neutrophil-related non-specific immunity.British journal of sports medicine · 2007Article
- Role of Hsp72 and norepinephrine in the moderate exercise-induced stimulation of neutrophils' microbicide capacity.European journal of applied physiology · 2006Article
- A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults.Sports medicine - openReview
- Leukocyte Subset Changes in Response to a 164-km Road Cycle Ride in a Hot Environment.International journal of exercise scienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged exercise may induce temporary immunosuppression with a presumed increased susceptibility for infection. However, there are only few data on immune cell function after prolonged cycling at moderate intensities typical for road cycling training sessions.
methodsThe present study examined the influence on immune cell function of 4 h of cycling at a constant intensity of 70% of the individual anaerobic threshold. Interleukin-6 (IL-6) and C-reactive protein (CRP), leukocyte and lymphocyte populations, activities of natural killer (NK), neutrophils, and monocytes were examined before and after exercise, and also on a control day without exercise.
resultsCycling for 4 h induced a moderate acute phase response with increases in IL-6 from 1.0 (SD 0.5) before to 9.6 (5.6) pg/ml 1 h after exercise and CRP from 0.5 (SD 0.4) before to 1.8 (1.3) mg/l 1 day after exercise. Although absolute numbers of circulating NK cells, monocytes, and neutrophils increased during exercise, on a per cell basis NK cell activity, neutrophil and monocyte phagocytosis, and monocyte oxidative burst did not significantly change after exercise. However, a minor effect over time for neutrophil oxidative burst was noted, tending to decrease after exercise.
conclusionsProlonged cycling at moderate intensities does not seem to seriously alter the function of cells of the first line of defence. Therefore, the influence of a single typical road cycling training session on the immune system is only moderate and appears to be safe from an immunological point of view.
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