ArticleProceedings of the National Academy of Sciences of the United States of America2005
Microsatellite instability regulates transcription factor binding and gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 187 citations in OpenAlex.
- Bacterial post-translational changes: the possible enigma of multidrug resistance.Archives of microbiology · 2026Review
- A 5'-UTR cis-acting RNA element targeted by RNase III is essential for DNA simple sequence repeat-dependent phase variation in Haemophilus influenzae.Nucleic acids research · 2025Article
- Unveiling the mitochondrial genome of Salvia splendens insights into the evolutionary traits within the genus Salvia.Scientific reports · 2025Article
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- Mitochondrial Genome Sequence ofInternational journal of molecular sciences · 2023Article
- Mining and analysis of microsatellites in human coronavirus genomes using the in-house built Java pipeline.Genomics & informatics · 2022Article
- STRs: Ancient Architectures of the Genome beyond the Sequence.Journal of molecular neuroscience : MN · 2021Review
- Genetic and molecular characterization of determinant of six-rowed spike of barley carrying vrs1.a4.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- An integrated strategy for target SSR genotyping with toleration of nucleotide variations in the SSRs and flanking regions.BMC bioinformatics · 2021Article
- Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom.Transcription · 2021Review
- Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.Nature communications · 2021Article
- Variable number tandem repeats - Their emerging role in sickness and health.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Genome-Wide Characterization of Lectin Receptor Kinases inPlants (Basel, Switzerland) · 2021Article
- Beyond Microsatellite Instability: Intrinsic Disorder as a Potential Link Between Protein Short Tandem Repeats and Cancer.Frontiers in bioinformatics · 2021Article
- Mutations of the cystic fibrosis transmembrane conductance regulator gene in males with congenital bilateral absence of the vas deferens: Reproductive implications and genetic counseling (Review).Molecular medicine reports · 2020Review
- The Amazonian Red Side-Necked TurtleCells · 2020Article
- Interaction between CA repeat microsatellites and HIF1α regulated the transcriptional activity of porcine IGF1 promoter.Journal of applied genetics · 2020Article
- Moraxella catarrhalis phase-variable loci show differences in expression during conditions relevant to disease.PloS one · 2020Article
- SSRome: an integrated database and pipelines for exploring microsatellites in all organisms.Nucleic acids research · 2019Article
- Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine.Journal of clinical microbiology · 2018Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsatellites are tandemly repeated simple sequence DNA motifs widely prevalent in eukaryotic and prokaryotic genomes. In pathogenic bacteria, instability of these hypermutable loci through slipped-strand mispairing mediates the high-frequency reversible switching of phenotype expression, i.e., phase variation. Phase-variable expression of NadA, an outer membrane protein and adhesin of the pathogen Neisseria meningitidis, is mediated by changes in the number of TAAA repeats located upstream of the core promoter of nadA. Here we report that loss or gain of TAAA repeats affects the binding of the transcriptional regulatory protein IHF to the nadA promoter. Thus, phase-variable transcription of nadA potentially incorporates interplay between stochastic (mutational) and prescriptive (classical) mechanisms of gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.