ArticleProceedings of the National Academy of Sciences of the United States of America2005
Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 223 citations in OpenAlex.
- Functional urine production and glomerular maturation from embryonic metanephros transplanted at the renal hilum in rats.Renal failure · 2026Article
- A Simple Mammalian Whole Embryo Culture System to Study High-Temperature Effects on Development.Acta histochemica et cytochemica · 2026Article
- Fetal-to-fetal kidney transplantation in utero.Communications biology · 2025Article
- Development of a Cryopreservation Technique for Xenogeneic Kidney Grafts: Evaluation Using a Mouse Model.Journal of clinical medicine · 2022Article
- Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response.Frontiers in immunology · 2022Article
- Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review.Bosnian journal of basic medical sciences · 2021Review
- Article
- Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models.Renal failure · 2020Article
- Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials.Small methods · 2020Article
- Kidney organoids in translational medicine: Disease modeling and regenerative medicine.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells.Stem cells international · 2020Review
- Kidney Regeneration in Later-Stage Mouse EmbryosJournal of the American Society of Nephrology : JASN · 2019Article
- Growing a new human kidney.Kidney international · 2019Review
- Reparative and Regenerative Effects of Mesenchymal Stromal Cells-Promising Potential for Kidney Transplantation?International journal of molecular sciences · 2019Review
- In vivo regeneration of interspecies chimeric kidneys using a nephron progenitor cell replacement system.Scientific reports · 2019Article
- Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration.Scientific reports · 2018Article
- Selective Activation of N,N'-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE).Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Current Perspectives on Role of MSC in Renal Pathophysiology.Frontiers in physiology · 2018Review
- Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system.Nature communications · 2017Article
- Effect of adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.Scientific reports · 2017Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of stem cells has enabled the successful generation of simple organs. However, anatomically complicated organs such as the kidney have proven more refractory to stem-cell-based regenerative techniques. Given the limits of allogenic organ transplantation, an ultimate therapeutic solution is to establish self-organs from autologous stem cells and transplant them as syngrafts back into donor patients. To this end, we have striven to establish an in vitro organ factory to build up complex organ structures from autologous adult stem cells by using the kidney as a target organ. Cultivation of human mesenchymal stem cells in growing rodent embryos enables their differentiation within a spatially and temporally appropriate developmental milieu, facilitating the first step of nephrogenesis. We show that a combination of whole-embryo culture, followed by organ culture, encourages exogenous human mesenchymal stem cells to differentiate and contribute to functional complex structures of the new kidney.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.