ArticleProceedings of the National Academy of Sciences of the United States of America2005
Circulating transcriptome reveals markers of atherosclerosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
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- Monocyte gene expression signature of patients with early onset coronary artery disease.PloS one · 2012Trial
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- Identification and validation of four hub genes involved in the plaque deterioration of atherosclerosis.Aging · 2019Article
- The Transcriptomic Toolbox: Resources for Interpreting Large Gene Expression Data within a Precision Medicine Context for Metabolic Disease Atherosclerosis.Journal of personalized medicine · 2019Article
- Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.British journal of clinical pharmacology · 2019Article
- Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease.Frontiers in genetics · 2019Article
- Microarray and proteome array in an atherosclerosis mouse model for identification of biomarkers in whole blood.International journal of medical sciences · 2019Article
- Mouse Homolog of the HumanCancer research · 2018Article
- Transcriptomic Signature of Atherosclerosis in the Peripheral Blood: Fact or Fiction?Current atherosclerosis reports · 2016Review
- Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells.Scientific reports · 2015Article
- Pathway and network approaches for identification of cancer signature markers from omics data.Journal of Cancer · 2015Review
- Association of FOS-like antigen 1 promoter polymorphism with podocyte foot process effacement in immunoglobulin A nephropathy patients.Journal of clinical laboratory analysis · 2014Article
- Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction.Free radical biology & medicine · 2014Article
- Towards a molecular systems model of coronary artery disease.Current cardiology reports · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Circulating monocytes mediate inflammation in atherosclerosis and may serve as easily accessible reporters of disease. To search for markers of atherosclerosis, we compared the in vivo transcriptomes of monocytes purified from patients undergoing carotid endarterectomy and normal subjects by using the serial analysis of gene expression technique. We selected a subset of differentially expressed monocyte-specific genes and confirmed their expression levels. The Finkel-Biskis-Jinkins osteosarcoma (FOS) gene was significantly increased in patients, and the highest levels of FOS associated with patients who had previously undergone coronary revascularization. The correlation between coronary revascularization and FOS was higher than that compared with the cardiac risk marker high sensitivity C-reactive protein. In vitro inhibition of FOS using small interfering RNA and 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitor simvastatin (statin) affected monocyte activation and suggested an important role in pathogenesis. Given the prominent role of FOS in inflammation and calcification, its association with atherosclerosis severity has clear pathophysiologic bases as well as clinical implications as a marker. Our results suggest that analysis of gene expression in circulating cells may provide biological and clinical insights into human atherosclerosis, and that this type of approach may be applicable for studying other types of diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.