ArticleProceedings of the National Academy of Sciences of the United States of America2005
Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 81 citations in OpenAlex.
- Nanoparticles in Vascular Dementia: Advantages and Challenges.CNS neuroscience & therapeutics · 2026Review
- IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression.Journal of advanced research · 2025Article
- Replicative Endothelial Cell Senescence May Lead to Endothelial Dysfunction by Increasing the BH2/BH4 Ratio Induced by Oxidative Stress, Reducing BH4 Availability, and Decreasing the Expression of eNOS.International journal of molecular sciences · 2024Article
- Combination of Bisphenol A and Its Emergent Substitute Molecules Is Related to Heart Disease and Exerts a Differential Effect on Vascular Endothelium.International journal of molecular sciences · 2023Article
- Dermal Fibroblasts as the Main Target for Skin Anti-Age Correction Using a Combination of Regenerative Medicine Methods.Current issues in molecular biology · 2023Review
- Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.Biomolecules · 2021Article
- Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway.Scientific reports · 2020Article
- Nitrite Improves Heart Regeneration in Zebrafish.Antioxidants & redox signaling · 2020Article
- Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications.Journal of nanobiotechnology · 2020Review
- Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer.Frontiers in oncology · 2019Review
- Article
- Integrin-linked kinase regulates endothelial cell nitric oxide synthase expression in hepatic sinusoidal endothelial cells.Liver international : official journal of the International Association for the Study of the Liver · 2015Article
- Hyperbaric oxygen, vasculogenic stem cells, and wound healing.Antioxidants & redox signaling · 2014Review
- Role of estrogen in diastolic dysfunction.American journal of physiology. Heart and circulatory physiology · 2014Review
- Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases.Cardiovascular research · 2012Review
- Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways.Clinical & experimental metastasis · 2012Article
- Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation.Human cell · 2012Article
- In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.PloS one · 2012Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the mechanisms by which NO elicits endothelial cell (EC) migration we used murine and bovine aortic ECs in an in vitro wound-healing model. We found that exogenous or endogenous NO stimulated EC migration. Moreover, migration was significantly delayed in ECs derived from endothelial NO synthase-deficient mice compared with WT murine aortic EC. To assess the contribution of matrix metalloproteinase (MMP)-13 to NO-mediated EC migration, we used RNA interference to silence MMP-13 expression in ECs. Migration was delayed in cells in which MMP-13 was silenced. In untreated cells MMP-13 was localized to caveolae, forming a complex with caveolin-1. Stimulation with NO disrupted this complex and significantly increased extracellular MMP-13 abundance, leading to collagen breakdown. Our findings show that MMP-13 is an important effector of NO-activated endothelial migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.